66768-15-8Relevant academic research and scientific papers
Studies on biotransformation of (±)-1-(4′-chlorophenyl)-2- phenylethanol
Bustillo, Antonio J.,Garcia-Pajon, Carlos M.,Aleu, Josefina,Hernandez-Galan, Rosario,Collado, Isidro G.
, p. 3755 - 3760 (2003)
The metabolism of (±)-1-(4′-chlorophenyl)-2-phenylethanol 1 by the phytopathogenic fungi Colletotrichum gloeosporioides and Botrytis cinerea has been studied. Regioselective monooxygenase-catalyzed hydroxylation of C-H bonds yielded the corresponding diols, the ratios of which showed a clear preference for the C-H benzylic bond. m-Hydroxylation in the substituted aromatic ring, a rarely described phenomenon, has been observed and with good enantioselectivity. The chemistry involved in determining the configuration of the biotransformation products is also described.
