66783-82-2

Upstream product

• 10183-83-2 N-(9H-fluoren-9-ylidene)-4-methylaniline 
• 2157-52-0 9-fluorenone oxime 
• 486-25-9 9-fluorenone 
• 106-49-0 p-toluidine 

Downstream Products

• 66783-75-3 3'-p-tolyl-dispiro[cyclohexane-1,4'-oxazolidine-2',9''-fluoren]-5'-one 
• 66783-76-4 4'-tert-butyl-5'-oxo-3'-p-tolyl-spiro[fluorene-9,2'-oxazolidine]-4'-carboxylic acid ethyl ester 
• 66783-78-6 4'-tert-butyl-5'-oxo-3'-p-tolyl-spiro[fluorene-9,2'-oxazolidine]-4'-carbonitrile 
• 486-25-9 9-fluorenone 

Relevant academic research and scientific papers

Metal-free synthesis of highly substituted quinolines under mild conditions Dedicated to Professor Jonathan S. Lindsey on his sixtieth birthday

Starting from easily accessible nitrones and acetylenes, a simple, metal free synthesis of substituted quinolines under mild conditions with high atom efficiency has been developed. Our method is flexible enough to introduce substituents regiospecifically

Cycloaddition of Fluorenone N-Aryl Nitrones with Methylenecyclopropanes and Sequential 1,3-Rearrangement: An Entry to Synthesis of Spirofluorenylpiperidin-4-ones

A facile synthesis of various spirofluorenylpiperidin-4-ones has been achieved in good yields from fluorenone N-aryl nitrones and methylenecyclopropanes. This method involved an initial cycloaddition to form a 5-spirocyclopropane-isoxazoline, which underwent a highly selective 1,3-rearrangement to give the desired product. The stereochemistry of the spirofluorenylpiperidin-4-one could be controlled by the cycloaddition and sequential rearrangement strategy. Furthermore, the spirofluorenylpiperidin-4-ones could be not only prepared in one-pot procedure but also converted to useful scaffolds by reduction or oxidation conditions.