667888-91-7Relevant academic research and scientific papers
Synthesis of antitumor 6-alkylidenepenicillanate sulfones and related 3-alkylidene-2-azetidinones
Veinberg, Grigory,Shestakova, Irina,Vorona, Maxim,Kanepe, Iveta,Lukevics, Edmunds
, p. 147 - 150 (2004)
6-Alkylidenepenicillanate sulfoxides and sulfones were synthesized on the base of 6-oxopenicillanate esters. The targeted splitting of their thiazolidine ring led to the formation of 3-alkylidene substituted 4-heteryldithio and 4-methylsulfonyl azetidin-2-ones. Some of mono and bicyclic β-lactams revealed potent cytotoxic properties towards monolayer tumor cells in 10-μM concentrations.
