667900-10-9Relevant academic research and scientific papers
Tetrahydronaphthalene-derived amino alcohols and amino ketones as potent and selective inhibitors of the delayed rectifier potassium current I Ks
Ahmad, Saleem,Doweyko, Lidia,Ashfaq, Aaila,Ferrara, Francis N.,Bisaha, Sharon N.,Schmidt, Joan B.,DiMarco, John,Conder, Mary Lee,Jenkins-West, Tonya,Normandin, Diane E.,Russell, Anita D.,Smith, Mark A.,Levesque, Paul C.,Lodge, Nicholas J.,Lloyd, John,Stein, Philip D.,Atwal, Karnail S.
, p. 99 - 102 (2007/10/03)
Class III anti-arrhythmic drugs (e.g., dofetilide) prolong cardiac action potential duration (APD) by blocking the fast component of the delayed rectifier potassium current (IKr). The block of IKr can result in life threatening ventr
Synthesis and aldose reductase inhibitory activity of a new series of benzo[h]cinnolinone derivatives
Costantino, Luca,Rastelli, Giulio,Cignarella, Giorgio,Barlocco, Daniela
, p. 544 - 552 (2007/10/03)
Following our previous studies on pyridazinone carboxylic acids as potent and selective aldose reductase (ALR2) inhibitors, a new series of benzo[h]cinnolinone carboxylic acids, variously substituted at the positions 4, 7-10 and differently modified both
