667909-77-5Relevant academic research and scientific papers
A convenient route for the synthesis of 4-aryl- and 4-aminopyrimidines
Jachak, Madhukar N.,Tantak, Chanda D.,Toche, Raghunath B.,Badgujar, Naresh S.
, p. 1529 - 1538 (2004)
A series of ureidopropenenitriles were synthesised by Knoevenagel condensation of ArCOCH2CN and HC(OEt)3 in presence of ureas in a one potreaction. These ureidopropenenitriles were cyclised to 4-aryl-5-cyano-3-substituted pyrimidines (in acid) or to 4-amino-5- benzoylpyrimidines (in base) in 60-70% yields. The amine pyrimidine derivatives were further converted to substituted uracils by hydrolysis with isopentyl nitrite in DMF. Alkylation of uracils furnished 1,3-dimethyluracil derivatives with DMS in alkali. All new compounds were characterised by spectral and analytical methods. Springer-Verlag 2004.
