667917-84-2

Basic information

• Product Name: methyl 4,5,7-tri-O-benzyl-2-O-methyl-α-D-gluco-hept-2-ulopyranosonate
• CAS NO: 667917-84-2
• Molecular Weight: 522.595
• Mol File: 667917-84-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl 4,5,7-tri-O-benzyl-2-O-methyl-α-D-gluco-hept-2-ulopyranosonate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4,5,7-tri-O-benzyl-2-O-methyl-α-D-gluco-hept-2-ulopyranosonate(667917-84-2)
• EPA Substance Registry System: methyl 4,5,7-tri-O-benzyl-2-O-methyl-α-D-gluco-hept-2-ulopyranosonate(667917-84-2)

Safety Data

• Hazardous Substances Data: 667917-84-2(Hazardous Substances Data)

Upstream product

• 404377-35-1 methyl 3-O-acetyl-4,5,7-tri-O-benzyl-α-D-gluco-hept-2-ulopyranosonate 

Downstream Products

• 667917-95-5 (3-acetamido-4,5,7-tri-O-benzyl-3-deoxy-2-O-methyl-α-D-mannno-hept-2-ulopyranos-1-yl) dibenzyl phosphate 
• 667917-87-5 methyl 3-acetamido-4,5,7-tri-O-benzyl-3-deoxy-2-O-methyl-α-D-manno-hept-2-ulopyranosonate 
• 667917-89-7 3-acetamido-4,5,7-tri-O-benzyl-3-deoxy-2-O-methyl-α-D-manno-hept-2-ulopyranose 
• 667917-85-3 methyl 3-azido-4,5,7-tri-O-benzyl-3-deoxy-2-O-methyl-α-D-manno-hept-2-ulopyranosonate 

Relevant articles and documents

Novel UDP-Glycal Derivatives As Transition State Analogue Inhibitors of UDP-GlcNAc 2-Epimerase

The "epimerisation" of UDP-GlcNAc to ManNAc, the first step in the biosynthesis of sialic acids, is catalyzed by UDP-GlcNAc 2-epimerase. In this paper we report the synthesis of transition state based inhibitors of this enzyme. To mimic the assumed first transition state of this reaction (TS 1), we designed and synthesized the novel UDP-exo-glycal derivatives 1-4. We also report herein the synthesis of 5 and 6, the first C-glycosidic derivatives of 2-acetamidoglucal, and the synthesis of the ketosides 7 and 8, which were designed as bis-substrate analogue and bis- product analogue, respectively, to mimic the second step of the reaction via the assumed second transition state TS 2.