66810-03-5Relevant academic research and scientific papers
Synthesis of 2-Substituted 2-Arylmalonates via Tricarbonylchromium Complexes
Deutsch,Bartoszek,Schneider,Zabel,Niclas
, p. 261 - 265 (1997)
Tricarbonylchromium complexes 1 react with monosubstituted malonic acid esters 2 in DMSO at room temperature in the presence of KOtBu to give the complexes 3. After oxidative demetalation, the appropriate aryl derivatives 4 are obtained in moderate to good overall yields. Diastereoselective arylations of chirally modified malonates such as 5a-c were studied. The stereoselectivity was highest for the products 6c/6c′ (80:20) with (-)-8-phenylmenthol as alcohol component in the malonate 5.
