668271-94-1

Basic information

• Product Name: 1H-Purine-2,6-dione, 8-bromo-7-(2-butynyl)-3,7-dihydro-3-methyl-1-(2-oxo-2-phenylethyl)-
• CAS NO: 668271-94-1
• Molecular Formula: C18H15BrN4O3
• Molecular Weight: 415.246
• Mol File: 668271-94-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1H-Purine-2,6-dione, 8-bromo-7-(2-butynyl)-3,7-dihydro-3-methyl-1-(2-oxo-2-phenylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Purine-2,6-dione, 8-bromo-7-(2-butynyl)-3,7-dihydro-3-methyl-1-(2-oxo-2-phenylethyl)-(668271-94-1)
• EPA Substance Registry System: 1H-Purine-2,6-dione, 8-bromo-7-(2-butynyl)-3,7-dihydro-3-methyl-1-(2-oxo-2-phenylethyl)-(668271-94-1)

Safety Data

• Hazardous Substances Data: 668271-94-1(Hazardous Substances Data)

Upstream product

• 666816-98-4 8-bromo-7-(but2-yn-1-yl)-3-methyl-3,7-dihydro-1H-purine-2,6–dione 
• 70-11-1 α-bromoacetophenone 

Relevant articles and documents

8-(3-(R)-aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin- 2-ylmethyl)-3,7-dihydropurine-2,6-dione (BI 1356), a highly potent, selective, long-acting, and orally bioavailable DPP-4 inhibitor for the treatment of type 2 diabetes

A new chemical class of potent DPP-4 inhibitors structurally derived from the xanthine scaffold for the treatment of type 2 diabetes has been discovered and evaluated. Systematic structural variations have led to 1 (BI 1356), a highly potent, selective, long-acting, and orally active DPP-4 inhibitor that shows considerable blood glucose lowering in different animal species. 1 is currently undergoing clinical phase IIb trials and holds the potential for once-daily treatment of type 2 diabetics.