668274-97-3

Upstream product

• 666816-89-3 1-[2-(2-nitro-phenyl)-2-oxo-ethyl]-3-methyl-7-((E)-2-buten-1-yl)-8-[(R)-3-(tert-butyloxycarbonylamino)-piperidin-1-yl]-2,6-dioxo-2,3,6,7-tetrahydro-1H-purine 

Downstream Products

• 690996-66-8 1-{2-[2-(2-chloro-acetylamino)-phenyl]-2-oxo-ethyl}-3-methyl-7-((E)-2-buten-1-yl)-8-[(R)-3-(tert-butyloxycarbonylamino)-piperidin-1-yl]-3,7-dihydro-1H-purine-2,6-dione 

Relevant academic research and scientific papers

NOVEL XANTHINE DERIVATIVES, THE PRODUCTION AND THE USE THEREOF IN THE FORM OF DRUGS

The invention relates to xanthines presented by a general formula (I), wherein R1 to R4 are equal to these defined in the claim n° 1, and to tautomers, stereoisomers, mixtures, pro-drugs and the salts thereof. Said compounds exhibit advantages pharmacological properties, in particular an inhibiting action on the activity of enzyme dipeptidylpeptidasa-IV (DPP-IV).

XANTHINE DERIVATIVES, PRODUCTION THEREOF AND USE THEREOF AS MEDICINES

The invention concerns substituted xanthines of general formula (I), wherein: R1 to R4 are such as defined in Claim 1, and tautomers, stereoisomers, mixtures, prodrugs and salts thereof. Said compounds have advantageous pharmacological properties, in particular an inhibiting effect on the activity of the dipeptidyl peptidase IV (DPP-IV) enzyme.