66842-60-2Relevant academic research and scientific papers
Stereoselective synthesis of optically active 1-benzyl-4,5,6,7-tetrahydro-6,6-dimethyl-4-oxo-1H-indol-7-yl acetate and 1-benzyl-6,7-dihydro-7-hydroxy-6,6-dimethyl-1H-indol-4(5H)-one through lipase-catalyzed esterification and transesterification processes
Caliskan, Zerrin Zerenler,Ersez, Mediha Suleymanoglu
, p. 64 - 70 (2015)
The enantioselective synthesis of 1-benzyl-4,5,6,7-tetrahydro-6,6-dimethyl-4-oxo-1H-indol-7-yl acetate (4) and 1-benzyl-6,7-dihydro-7-hydroxy-6,6-dimethyl-1H-indol-4(5H)-one (5), which are important intermediates in pharmaceutical industry, was carried ou
One-pot Synthesis of Dihydrofuran Derivatives by Ru Catalyzed Reaction
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Paragraph 0170-0172, (2016/10/10)
The present invention relates to a one-pot synthesis method of dihydrofuran derivatives using a ruthenium catalyst and, more particularly, to a one-pot synthesis method of dihydrofuran derivatives, which makes a reaction between cyclic/non-cyclic diazo dicarbonyl compound and olefin in the presence of ruthenium (II) phosphine complex as a reaction catalyst. The one-pot synthesis method of the present invention shortens time required for the reaction and improves synthesis yield. The diazo carbonyl compound represented by chemical formula 1, 2, or 3 reacts with olefin to form dihydrofuran derivatives through a [3+2] cyclization addition reaction.COPYRIGHT KIPO 2016
Efficient one-pot synthesis of multi-substituted dihydrofurans by ruthenium(II)-catalyzed [3+2] cycloaddition of cyclic or acyclic diazodicarbonyl compounds with olefins
Xia, Likai,Lee, Yong Rok
, p. 2361 - 2374 (2013/10/01)
Ruthenium(II)-phosphine complexes-catalyzed [3+2] cycloadditions were conducted to synthesize a variety of dihydrofurans by reactions of cyclic or acyclic diazodicarbonyl compounds with olefins. This method represents a direct and efficient one-pot synthesis for multi-substituted dihydrofurans under mild reaction conditions with an excellent regioselectivity. Furthermore, to reduce reaction times and increase yields of dihydrofurans, microwave-as sisted tris(triphenylphosphine)ruthenium(II) chloride/ 1-butyl-3-methylimidazolium tetrafluoroborate {Ru (PPh3)3Cl2/ [Bmim]BF4}-catalyzed reactions were also developed. The synthesized dihydrofurans can be readily converted into biologically interesting tetrahydroindoles.
