668420-23-3

Upstream product

• 668419-17-8 N-[2-(1H-indol-3-yl)-1-methylethyl]-2,4,6-trimethyl-benzenesulfonamide 
• 34619-03-9 tert-butyldicarbonate 
• 299-26-3 1-(1H-indol-3-yl)propan-2-amine 
• 773-64-8 2-mesitylenesulphonyl chloride 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 668420-24-4 3-{2-[methyl-(2,4,6-trimethylbenzenesulfonyl)amino]propyl}indole-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

α-Methyltryptamine sulfonamide derivatives as novel glucocorticoid receptor ligands

α-Methyltryptamine sulfonamides were identified as human glucocorticoid receptor (hGR) ligands in an ultra high throughput screening (UHTS) campaign. Described will be the hit-to-lead activities, including parallel and single point analog synthesis to map the scaffold. Ligands were identified that exhibited 30 nM binding to hGR. The SAR and selectivity of these compounds will be discussed.

-3 (SULFONAMIDOETHYL) -INDOLE DERIVATIES FOR USE AS GLUCOCORTICOID MIMETICS IN THE TREATMENT OF INFLAMMATORY, ALLERGIC AND PROLIFERATIVE DISEASES

Compounds of Formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, and Y are as defined herein, or a tautomer, prodrug, solvate, or sal