668475-87-4Relevant articles and documents
Synthesis of 2-Hydroxymethyl-1H-imidazoles from 1,3-Dihydroimidazole-2- thiones
Loksha, Yasser M.,El-Barbary, Ahmed A.,El-Badawi, Mahmoud A.,Nielsen, Claus,Pedersen, Erik B.
, p. 116 - 120 (2004)
1,3-Dihydroimidazole-2-thiones 1a-d were desulfurized by hydrogen peroxide in either acid or neutral medium to afford 1H-imidazoles 3a-d. Reaction of 3b,d with dimethylsulfamoyl chloride furnished N,N-dimethylsulfamoylimidazoles 5 and 6a,b. Lithiation of 5 and 6a,b followed by formylation and reduction yielded the 2-hydroxymethyl derivatives 7 and 8a,b. 4-Alkyl-5-cyclohexylmethyl-1H- imidazol-2-yl)methanols 9a,b were obtained by hydrolysis of 7 and 8a,b.