66849-33-0

Basic information

• Product Name: (2S)-N,3-bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide
• CAS NO: 66849-33-0
• Molecular Formula: C₇H₁₅Cl₂N₂O₂P
• Molecular Weight: 261.086
• Mol File: 66849-33-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 336.099°C at 760 mmHg
• Flash Point: 157.068°C
• Density: 1.334g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.506
• CAS DataBase Reference: (2S)-N,3-bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-N,3-bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide(66849-33-0)
• EPA Substance Registry System: (2S)-N,3-bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide(66849-33-0)

Safety Data

• Hazardous Substances Data: 66849-33-0(Hazardous Substances Data)

Relevant articles and documents

Process for the preparation of oxazaphosphorine-2-amines

A process for the preparation of oxazaphosphorine-2-amines of the formula (I) described by the reaction scheme in which R1 is H, 2-bromoethyl, 2-chloroethyl, 2-hydroxyethyl, 2-mesyloxyethyl or 1-phenylethyl; R2 is H or 2-chloroethyl; R3 is H, 2-bromoethyl, 2-chloroethyl or 1-phenylethyl; and R4 is H; or R1 and R2, and also R3 and R4, together with the linked N atom, form an aziridide ring, where R1, R2 and R3 are not simultaneously H, and R1 and R3 are not simultaneously 1-phenylethyl; and Y, which is optionally present, is hydrogen chloride or hydrogen bromide. The reaction is carried out in a single vessel with phosphoryl chloride and an auxiliary base as an acid-binding agent with minimization of the effect of water and without isolation of an intermediate compound.