66852-00-4

Basic information

• Product Name: L-Leucine, N-[(1,1-dimethylethoxy)carbonyl]-L-tyrosyl-, methyl ester
• CAS NO: 66852-00-4
• Molecular Formula: C21H32N2O6
• Molecular Weight: 408.495
• Mol File: 66852-00-4.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: L-Leucine, N-[(1,1-dimethylethoxy)carbonyl]-L-tyrosyl-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Leucine, N-[(1,1-dimethylethoxy)carbonyl]-L-tyrosyl-, methyl ester(66852-00-4)
• EPA Substance Registry System: L-Leucine, N-[(1,1-dimethylethoxy)carbonyl]-L-tyrosyl-, methyl ester(66852-00-4)

Safety Data

• Hazardous Substances Data: 66852-00-4(Hazardous Substances Data)

Usage

General Description

L-Leucine, N-[(1,1-dimethylethoxy)carbonyl]-L-tyrosyl-, methyl ester is a chemical compound that is commonly used in the field of biochemistry and pharmaceutical research. It is a methyl ester derivative of the amino acids L-leucine and L-tyrosine, and is often employed as a building block in the synthesis of peptide and protein-based drugs. L-Leucine, N-[(1,1-dimethylethoxy)carbonyl]-L-tyrosyl-, methyl ester is known for its ability to enhance protein synthesis and promote muscle growth, making it a popular ingredient in sports nutrition supplements and muscle-building products. Additionally, it has also been investigated for its potential therapeutic applications in the treatment of conditions such as muscle wasting and neurodegenerative diseases. Overall, L-Leucine, N-[(1,1-dimethylethoxy)carbonyl]-L-tyrosyl-, methyl ester is a versatile and valuable chemical with numerous biological and pharmacological properties.

Upstream product

• 2666-93-5 (S)-Leu-OMe 
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• 3978-80-1 Boc-Tyr-OH 
• 7517-19-3 methyl (L)-leucinate hydrochloride 
• 24424-99-5 di-tert-butyl dicarbonate 
• 61-90-5 L-leucine 
• 60-18-4 L-tyrosine 

Downstream Products

• 71641-29-7 Boc-tyrosinyl-leucine 
• 1447815-64-6 L-isoseryl-L-tyrosyl-L-leucine 
• 1575822-58-0 Boc-DOPA-Leu-OMe 
• 80066-35-9 Boc-Val-Tyr-Val-Gln-Leu-Tyr-Leu-NH-NH₂ 
• 80066-34-8 Boc-Val-Tyr-Val-Gln-Leu-Tyr-Leu-OMe 
• 80066-38-2 Boc-Tyr-Val-Gln-Leu-Tyr-Leu-OMe 
• 80066-33-7 Boc-Val-Gln-Leu-Tyr-Leu-OMe 
• 80066-32-6 Boc-Gln-Leu-Tyr-Leu-OMe 
• 919769-26-9 Boc-nitroargininyl-tyrosinyl-leucyl-prolyl-threonine p-nitrophenyl ester 
• 919769-24-7 Boc-nitroargininyl-tyrosinyl-leucyl-prolyl-threonine methyl ester 
• 919769-22-5 tyrosinyl-leucyl-prolyl-threonine methyl ester 
• 919769-23-6 Boc-tyrosinyl-leucyl-prolyl-threonine methyl ester 
• 80066-31-5 Boc-Leu-Tyr-Leu-OMe 

Relevant articles and documents

ACYLATION OF TYROSINE UNITS IN PEPTIDE COMPOUNDS

The present invention refers to a process for the selective modification of tyrosine units in a peptide sequence, in particular, by incorporating acyl groups in the ortho position of the hydroxyl residue of its aromatic ring. Likewise, the invention also

Design, synthesis and biological evaluation of novel L-isoserine tripeptide derivatives as aminopeptidase N inhibitors

Aminopeptidase N (APN/CD13) is one of the essential proteins for tumour invasion, angiogenesis and metastasis as it is over-expressed on the surface of different tumour cells. Based on our previous work that L-isoserine dipeptide derivatives were potent APN inhibitors, we designed and synthesized L-isoserine tripeptide derivatives as APN inhibitors. Among these compounds, one compound 16l (IC50=2.51±0.2 M) showed similar inhibitory effect compared with control compound Bestatin (IC50=6.25±0.4 M) and it could be used as novel lead compound for the APN inhibitors development as anticancer agents in the future.

Synthetic and biological activity studies on a new cyclic pentapeptide, cyclonitroproctolin

The synthesis of a new biologically active cyclic pentapeptide, cyclonitroproctolin, cyclo(-Arg (NO2)-Tyr-Leu-Pro-Thr-) by solution phase synthesis is described. The structure of the synthetic peptide was characterized by IR, NMR, FAB mass and