66854-78-2

Upstream product

• 501-53-1 benzyl chloroformate 
• 72-18-4 L-valine 
• 1149-26-4 (S)-N-(benzyloxycarbonyl)valine 
• 530-62-1 1,1'-carbonyldiimidazole 
• 288-32-4 1H-imidazole 

Downstream Products

• 137271-80-8 [(S)-2-Methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propyl]-carbamic acid benzyl ester 
• 137331-58-9 [(S)-2-Methyl-1-((3S,4R)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propyl]-carbamic acid benzyl ester 
• 1345680-37-6 (S)-methyl 2-(3-((S)-1-(benzyloxycarbonylamino)-2-methylpropyl)ureido)-3-phenylpropanoate 
• 95187-97-6 4-(benzyloxycarbonyl)amino-5-methyl-3-oxohexansaeure-aethylester 
• 124817-99-8 (3S,4R)-andrimid 
• 234752-13-7 (5S)-3-methyl-5-(2-propyl)pyrrolidine-2,4-dione 
• 234752-14-8 methyl (3S)-2,5-dimethyl-3-oxo-4-[(N-phenylmethoxycarbonyl)amino]hexanoate 
• 118916-87-3 (S)-ethyl 4-(benzyloxycarbonylamino)-5-methyl-3-oxohexanoate 

Relevant academic research and scientific papers

Carbonyldiimidazole (CDI) mediated synthesis of Nα- protected amino acid azides: Application to the one-pot preparation of ureidopeptides

Synthesis of Nα-protected amino acyl azides starting from corresponding acids via the carbonyldiimidazole (CDI) activation is described. The protocol is extended for a one-pot preparation of ureido peptides that circumvents the isolation of acy

Cyclic amine compounds

The present invention relates to pharmaceutical agents which are agents for the prophylaxis or treatment of hypogonadism, male climacteric disorder, frailty, cachexia or osteoporosis; the pharmaceutical agents frailty suppressants, muscle strength enhance

2(3H)-and 2(5H)-furanones. VIII. Preparation and α nucleophilicity of (S)-γ-isopropyl-α-methyl-β-tetramic acid

An efficient preparation of (S)-γ-isopropyl-α-methyl-β-tetramic acid has been established, and the α nucleophilicity of the acid has been also examined.

Synthesis and antitumor activity of novel dolastatin 10 analogs

Dolastatin 10 (1) is a potent antineoplastic pentapeptide. Novel dolastatin 10 analogs each modified at one of the constituent amino acid derivatives, were synthesized and their antitumor activity was evaluated against P388 leukemia in mice. The structural requirements for antitumor activity are discussed. Some of the analogs, 31c, 35c, 38b, and 50c showed excellent activity in vivo. Highly active 50c, which lacks the thiazole group of 1, was selected for further development as an antitumor agent.

Enantioselective and diastereoselective formation of syn-3-hydroxy-4-amino acids (syn-statines) via tetramic acids

Enantiomerically pure pyrrolidine-2,4-diones (tetramic acids) which can be diastereoselectively hydrogenated to syn-statines (4-amino-3-hydroxy-6-methylheptanoic acids) have been prepared by catalytic hydrogenation of 4-(benzyloxycarbonylamino)-3-oxocarboxylic acid esters.

A convenient diastereoselective total synthesis of andrimid

A convenient diastereoselective synthesis of andrimid was accomplished in a straightforward approach and also several β-substituted cyclic imides were prepared in a facile manner.