6686-70-0

Basic information

• Product Name: DESTRUXIN A
• Synonyms: DESTRUXIN A;destruxin A from metarhizium anisopliae;3-Ethenylcyclo(D-Lac-L-Pro-L-Ile-N-methyl-L-Val-N-methyl-L-Ala-βAla-);N-[N-[(2R)-1-Oxo-2-hydroxy-4-pentenyl]-L-Pro-L-Ile-N-methyl-L-Val-N-methyl-L-Ala-]-β-alanine lactone;N-[N-[(R)-2-Hydroxy-1-oxo-4-pentenyl]-L-Pro-L-Ile-N-methyl-L-Val-N-methyl-L-Ala-]-β-alanine lactone;Destruxin A from Metarrhizium anisopliae;Destruxin A, 98%, from Metarhizium anisopliae
• CAS NO: 6686-70-0
• Molecular Formula: C29H47N5O7
• Molecular Weight: 577.71
• Product Categories: Apoptosis and Cell Cycle;Cell Cycle;Cell Cycle Regulators
• Mol File: 6686-70-0.mol
• Article Data: 0

Chemical Properties

• Melting Point: 188-189 °C
• Boiling Point: 875.6°C at 760 mmHg
• Flash Point: 483.3°C
• Appearance: /
• Density: 1.18g/cm³
• Vapor Pressure: 3.74E-31mmHg at 25°C
• Refractive Index: 1.543
• Storage Temp.: −20°C
• PKA: 13.53±0.70(Predicted)
• CAS DataBase Reference: DESTRUXIN A(CAS DataBase Reference)
• NIST Chemistry Reference: DESTRUXIN A(6686-70-0)
• EPA Substance Registry System: DESTRUXIN A(6686-70-0)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38-48
• Safety Statements: 26-36-45
• WGK Germany: 3
• RTECS: HH1500000
• Hazardous Substances Data: 6686-70-0(Hazardous Substances Data)

Usage

Uses

Destruxin A from Metarrhizium anisopliae has been used for immersion and inoculation bioassay in Rhipicephalus (Boophilus) microplus. It has been used as a transport inhibitor in Drosophila melanogaster.

Biochem/physiol Actions

Destruxin A is a cyclic hexadepsipeptide produced by fungus causing paralysis and death in insects. May suppress the insect immune response. Possesses an inhibitory activity on leukemic cell proliferation, decreasing the number of cells in G2/M phase. It is virustatic against arboviruses.

InChI:InChI=1/C29H47N5O7/c1-9-12-21-27(38)34-16-11-13-20(34)26(37)31-23(18(5)10-2)28(39)33(8)24(17(3)4)29(40)32(7)19(6)25(36)30-15-14-22(35)41-21/h9,17-21,23-24H,1,10-16H2,2-8H3,(H,30,36)(H,31,37)