66866-69-1

Usage

Uses

Used in Biochemistry and Pharmaceutical Research:
H-D-LEU-OME HCL is used as a building block for the synthesis of peptides and other organic compounds, contributing to the development of new drugs and therapeutic agents.
Used in Drug Development:
In the pharmaceutical industry, H-D-LEU-OME HCL is utilized in the development of new drugs and therapeutic agents, leveraging its potential pharmaceutical properties to address various health conditions.
Used in Muscle Metabolism Research:
H-D-LEU-OME HCL has been studied for its potential role in improving muscle metabolism and promoting muscle gain, although more research is required to fully understand its biological effects and applications in this area.

Upstream product

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• 53363-89-6 N-t-butoxycarbonyl-N-methyl-L-leucine 
• 61-90-5 L-leucine 
• 13139-15-6 N-tert-butoxycarbonyl-L-leucine 
• 202273-39-0 (S)-3-Chloromethyl-4-isobutyl-2,2-bis-trifluoromethyl-oxazolidin-5-one 
• 6458-39-5 (S)-4-isobutyl-2,2-bis-trifluoromethyl-oxazolidin-5-one 

Relevant academic research and scientific papers

Preparation method of N-trimethyl silicon ethoxycarbonyl-N-methyl-L/D-leucine

The invention relates to a preparation method of N-(trimethylsilyl) ethoxycarbonyl group-N-methyl-L/D-leucine. The preparation method comprises the following steps: adding N-methyl-L/D-leucine hydrochloride, a trimethylsilylethoxycarbonyl protecting group reagent and alkali into a mixed solution of a polar solvent and water, and carrying out a reaction, so as to obtain the N-trimethylsilylethoxycarbonyl-N-methyl-L/D-leucine. According to the preparation method, the N-trimethyl silicon ethoxycarbonyl-N-methyl-L/D-leucine with high chiral purity, high chemical purity and high yield can be obtained, the chiral purity and the chemical purity can reach 99% or above, the yield can reach 60% or above, and the preparation method is simple in process, mild in condition and suitable for being applied to large-scale industrial production.

An efficient synthesis of N-methylamino acids and some of their derivatives

N-Methylamino acid derivatives are obtained in high yield by a stereoselective one-pot procedure from hexafluoroacetone protected amino acids via N-chloromethylation and treatment with triethylsilane/trifluoroacetic acid.