66872-16-0

Upstream product

• 57561-94-1 benzhydryl 2-<2-oxo-3β-(phenoxyacetamido)-4-(benzothiazol-2-yldithio)azetidine-1-yl>-2-isopropenylacetate 
• 106469-43-6 (2R,3R,7S)-3-Fluoro-3-methyl-5,8-dioxo-7-(2-phenoxy-acetylamino)-5λ⁴-thia-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester 
• 10209-10-6 diphenylmethyl (6R,7R)-3-methyl-7β-phenoxyacetamidoceph-3-em-4-carboxylate 
• 292638-85-8 acrylic acid methyl ester 

Relevant academic research and scientific papers

Chemistry of Cephems: C-4 Substitution and Sulphoxide De-oxygenation Reactions.

The anion derived from ceph-3-em esters adds readily to Michael acceptors to give C-4 disubstituted ceph-2-ems.Oxidation of a typical adduct, such as the 4-cyanoethyl-4-diphenylmethyl ester, followed by ester hydrolysis and decarboxylation, gives the 4-cyanoethylceph-3-em sulphoxide which is easily reduced to the sulphide.Furthermore, zinc-acetic acid in DMF (dimethylformamide) is found to be an effective, mild reagent for the de-oxygenation of ceph-2-em sulphoxides.

The Reaction of Metal Fluorides with unsym-Azetidinone Disulfides and 2β-(Halomethyl)penams. The 3β-Fluoro-3α-methylcephams

Fluorination studies on unsym-azetidinone disulfides and 2β-penams with metal fluorides are described.The unsym-azetidinone disulfides with AgF, in CH2Cl2, produce the 3β-fluoro-3α-methylcephams in low yields.The reaction of the 2