66873-47-0

Upstream product

• 66873-39-0 thyrsiferol 
• 108-24-7 acetic anhydride 
• 82188-73-6 (2S,3S)-2,3-epoxygeraniol 
• 52813-63-5 (5R)-2,3,4,5-tetrahydro-5-hydroxymethyl-2-furanone 
• 304466-03-3 Acetic acid (S)-1-[(2R,5R)-5-(1-acetoxy-1-methyl-ethyl)-2-methyl-tetrahydro-furan-2-yl]-4-[(2R,4aR,6R,8aS)-6-((2S,5R)-5-bromo-2,6,6-trimethyl-tetrahydro-pyran-2-yl)-8a-methyl-octahydro-pyrano[3,2-b]pyran-2-yl]-4-oxo-butyl ester 
• 304466-01-1 Acetic acid (E)-(S)-1-[(2R,5R)-5-(1-acetoxy-1-methyl-ethyl)-2-methyl-tetrahydro-furan-2-yl]-4-[(2R,4aR,6R,8aS)-6-((2S,5R)-5-bromo-2,6,6-trimethyl-tetrahydro-pyran-2-yl)-8a-methyl-octahydro-pyrano[3,2-b]pyran-2-yl]-4-oxo-but-2-enyl ester 
• 304466-00-0 Acetic acid (E)-(S)-1-[(2R,5R)-5-(1-acetoxy-1-methyl-ethyl)-2-methyl-tetrahydro-furan-2-yl]-4-[(2R,4aR,6R,8aS)-6-((2S,5R)-5-bromo-2,6,6-trimethyl-tetrahydro-pyran-2-yl)-8a-methyl-octahydro-pyrano[3,2-b]pyran-2-yl]-4-hydroxy-but-2-enyl ester 
• 240133-67-9 3-((2S,3R,6R)-6-Benzyloxymethyl-2-methyl-3-triethylsilanyloxy-tetrahydro-pyran-2-yl)-1-((2S,5R)-5-bromo-2,6,6-trimethyl-tetrahydro-pyran-2-yl)-propynone 
• 240133-66-8 3-((2S,3R,6R)-6-Benzyloxymethyl-2-methyl-3-triethylsilanyloxy-tetrahydro-pyran-2-yl)-1-((2S,5R)-5-bromo-2,6,6-trimethyl-tetrahydro-pyran-2-yl)-prop-2-yn-1-ol 
• 240133-56-6 ((2S,3R,6R)-6-Benzyloxymethyl-2-bromoethynyl-2-methyl-tetrahydro-pyran-3-yloxy)-triethyl-silane 
• 304465-93-8 1-((2S,5R)-5-Bromo-2,6,6-trimethyl-tetrahydro-pyran-2-yl)-3-((2S,3R,6R)-3-hydroxy-6-hydroxymethyl-2-methyl-tetrahydro-pyran-2-yl)-propan-1-one 
• 304465-85-8 C₂₄H₂₇BrO₅ 
• 240133-63-5 {(R)-1-Benzyloxymethyl-3-[(2R,3R)-3-(2,2-dibromo-vinyl)-3-methyl-oxiranyl]-propoxy}-tert-butyl-dimethyl-silane 
• 240133-62-4 (E)-(R)-7-Benzyloxy-6-(tert-butyl-dimethyl-silanyloxy)-2-methyl-hept-2-enoic acid ethyl ester 

Relevant academic research and scientific papers

Total synthesis of thyrsiferyl 23-acetate, a specific inhibitor of protein phosphatase 2A and an anti-leukemic inducer of apoptosis

A convergent synthetic entry to the squalenoid polyether system has been developed and applied to the biologically active marine natural products thyrsiferyl 23-acetate (1a), thyrsiferol (1b), thyrsiferyl 18-acetate (1c), and thyrsiferyl 18,23-diacetate (

Teurilene and thyrsiferyl 23-acetate, meso and remarkably cytotoxic compounds from the marine red alga Laurencia obtusa (Hudson) Lamouroux

Two new cyclic ethers consisting of a squalene carbon skeleton have been isolated from the red alga L. obtusa. The absolute stereostructure of teurilene was elucidated by the X-ray crystallographic method, and the structure of thyrsiferyl 23-acetate was established from spectral and chemical evidence.

TERPENOIDS OF THE RED ALGA LAURENCIA PINNATIFIDA

The structures of three brominated terpenoids which are natural products from the red alga Laurencia pinnatifida (Gmal.Lamour) are described.The structures of the sesquiterpenes 4 and 5 were determined by spectral comparison and chemical interconversion.The structure of the squalene-derived terpenoid 8 was secured by chemical transformation into thyrsiferol, a brominated triterpene previously isolated from the red alga Laurencia thyrsifera.