66891-86-9Relevant academic research and scientific papers
PRODRUGS ACTIVATED BY REACTIVE OXYGEN SPECIES FOR USE IN THE TREATMENT OF INFLAMMATORY DISEASES AND CANCER
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, (2018/09/25)
Prodrugs activated predominantly or exclusively in inflammatory tissue, more particularly prodrugs of methotrexate and derivatives thereof, which are selectively activated by Reactive Oxygen Species (ROS) in inflammatory tissues associated with cancer and inflammatory diseases, as well as method for preparing said prodrugs.
PYRAZOLE COMPOUNDS AND THIAZOLE COMPOUNDS AS PROTEIN KINASES INHIBITORS
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, (2013/03/26)
A compound of formula (I): wherein A, B, D, X, Y, R1, R2, R3, m, p, and q are defined herein. Also disclosed is a method for inhibiting FMS-like tyrosine kinase 3, aurora kinase, or vascular endothelial growth factor receptor.
Helical structures of N-alkylated poly(p-benzarnide)s
Tanatani, Aya,Yokoyama, Akihiro,Azumaya, Isao,Takakura, Yoshinori,Mitsui, Chikashi,Shiro, Motoo,Uchiyama, Masanobu,Muranaka, Atsuya,Kobayashi, Nagao,Yokozawa, Tsutomu
, p. 8553 - 8561 (2007/10/03)
Poly(p-benzamide)s 1 bearing a chiral side chain on the nitrogen atom were synthesized by chain-growth polycondensation methodology. The polyamides exhibited well-defined molecular weights with narrow polydispersities. Solutions of the polyamides in sever
Total synthesis of methotrexate-γ-TRIS-fatty acid conjugates
Francis, Craig L.,Yang, Qi,Hart, Noel K.,Widmer, Fred,Manthey, Michael K.,He-Williams, H. Ming
, p. 635 - 645 (2007/10/03)
Several routes for the regiospecific synthesis of lipophilic γ-conjugates of methotrexate are described. Coupling of methotrexate-α-tert-butyl ester with glycyl-TRIS-(mono-/di-/tri-)palmitate followed by trifluoroacetic acid cleavage of the α-protection a
