66892-54-4

Basic information

• Product Name: 2,3-DIHYDRO-2'H,5'H-SPIRO[CHROMENE-4,4'-IMIDAZOLIDINE]-2',5'-DIONE
• Synonyms: 2,3-DIHYDRO-2'H,5'H-SPIRO[CHROMENE-4,4'-IMIDAZOLIDINE]-2',5'-DIONE;SPIRO[CHROMANE-4,4-IMIDAZOLIDINE]-2,5-DIONE
• CAS NO: 66892-54-4
• Molecular Formula: C11H10N2O3
• Molecular Weight: 218.21
• Mol File: 66892-54-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 236-238 °C
• Appearance: /
• Density: 1.44±0.1 g/cm3(Predicted)
• PKA: 9.45±0.20(Predicted)
• CAS DataBase Reference: 2,3-DIHYDRO-2'H,5'H-SPIRO[CHROMENE-4,4'-IMIDAZOLIDINE]-2',5'-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-DIHYDRO-2'H,5'H-SPIRO[CHROMENE-4,4'-IMIDAZOLIDINE]-2',5'-DIONE(66892-54-4)
• EPA Substance Registry System: 2,3-DIHYDRO-2'H,5'H-SPIRO[CHROMENE-4,4'-IMIDAZOLIDINE]-2',5'-DIONE(66892-54-4)

Safety Data

• Hazardous Substances Data: 66892-54-4(Hazardous Substances Data)

Usage

General Description

2,3-Dihydro-2'H,5'H-spiro[chromene-4,4'-imidazolidine]-2',5'-dione, also known as spirocyclopentane chromene-imidazolidinedione, is a chemical compound with a unique spirocyclic structure. It is a heterocyclic compound containing a chromene ring fused to an imidazolidine ring, and it has a molecular formula of C15H15N3O3. 2,3-DIHYDRO-2'H,5'H-SPIRO[CHROMENE-4,4'-IMIDAZOLIDINE]-2',5'-DIONE has potential applications in medicinal chemistry and drug discovery due to its interesting structural features and potential biological activities, including antioxidant, anticancer, and antibacterial properties. Further research is needed to fully understand its potential therapeutic uses and mechanisms of action.

Upstream product

• 491-37-2 2,3-dihydro-4H-1-benzopyran-4-one 
• 151-50-8 potassium cyanide 
• 506-87-6 ammonium carbonate 

Downstream Products

• 851170-89-3 2-(2',5'-dioxospiro [chroman-4,4'-imidazolidine]-1'-yl)acetic acid 

Relevant articles and documents

TARGETED BIFUNCTIONAL DEGRADERS

The present invention provides, in one aspect, bifunctional compounds that can be used to promote or enhance degradation of certain circulating proteins. In another aspect, the present invention provides bifunctional compounds that can be used to promote or enhance degradation of certain autoantibodies. In certain embodiments, treatment or management of a disease and/or disorder requires degradation, removal, or reduction in concentration of the circulating protein or the autoantibody in the subject. Thus, in certain embodiments, administration of a compound of the invention to the subject removes or reduces the circulation concentration of the circulating protein or the autoantibody, thus treating, ameliorating, or preventing the disease and/or disorder. In certain embodiments, the circulating protein is TNF.

TRICYCLIC MODULATORS OF TNF SIGNALING

The invention provides tricyclic heterocyclic compounds, pharmaceutically acceptable salts, prodrugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variables are defined herein. The compounds of the invention may be useful for treating immunological and oncological conditions.

Hydantoin derivatives as therapeutic agents

A series of spiro-hydantoin compounds has been prepared by condensing the appropriate carbonyl ring compound, such as the corresponding 1-indanone, 1-tetralone, 4-chromanone, thiochroman-4-one, 7,8-dihydroquinolin-5(6H)-one, 6,7-dihydropyrindin-5(5H)-one, thiondane-3-one-1,1-dioxide and 4-oxoisothiochroman-2,2-dioxide, respectively, with potassium cyanide and ammonium carbonate. The resulting hydantoin derivatives are found to be useful in preventing or alleviating chronic diabetic complications. Preferred member compounds include spiro-[imidazolidine-4,1'-indan]-2,5-dione, 6-fluoro-spiro-[chroman-4,4'-imidazolidine]-2',5'-dione, 6-chloro-spiro-[chroman-4,4'-imidazolidine]-2',5'-dione, 6,7-dichloro-spiro-[chroman-4,4'-imidazolidine]-2',5'-dione, 6,8-dichloro-spiro-[chroman-4,4'-imidazolidine]-2',5'-dione, 6'-fluoro-spiro-[imidazolidine-4,4'-thiochroman]-2,5-dione and 6',7'-dichloro-spiro-[imidazolidine-4,4'-thiochroman]-2,5-dione.