66894-11-9Relevant academic research and scientific papers
First regioselective iodocyclization reaction of 3-aryl-5-(prop-2-ynylthio)-1H-1,2,4-triazoles
Rode, Navnath D.,Sonawane, Amol D.,Garud, Dinesh R.,Joshi, Rohini R.,Joshi, Ramesh A.,Likhite, Anjali P.
, p. 5140 - 5144 (2015)
The regioselective iodocyclization reaction of 3-aryl-5-(prop-2-ynylthio)-1H-1,2,4-triazoles is described for the first time. The iodocyclization reaction of 3-aryl-5-(prop-2-ynylthio)-1H-1,2,4-triazoles using molecular iodine afforded diiodo-compound which on CuI-catalyzed intramolecular C-N coupling reaction gave six-membered 2-aryl-5H-[1,2,4]triazolo[5,1-b][1,3]thiazines, whereas, the five membered 3-aryl-5,6-dihydrothiazolo[2,3-c][1,2,4]triazoles were obtained exclusively when the iodocyclization reaction of 3-aryl-5-(prop-2-ynylthio)-1H-1,2,4-triazoles was carried out using NIS.
Structural elucidation of propargylated products of 3-substituted-1,2, 4-triazole-5-thiols by NMR techniques
Chaudhary, Preeti M.,Chavan, Sayalee R.,Kavith,Maybhate, Shailaja P.,Deshpande, Sunita R.,Likhite, Anjali P.,Rajamohanan
experimental part, p. 1168 - 1174 (2009/05/26)
Propargylation of 3-substituted-1,2,4-triazole-5-thiols, which predominantly exist as their thione tautomers, was carried out with the view to synthesize different heterocycles and study their biological activity. Three different products namely, a mono S-propargyl and two S,N-dipropargyl regioisomers, arising from N1/N2 substitution, were isolated and characterized. Unambiguous structural elucidation of the regioisomers of S,N-dipropargyl derivatives was achieved by means of 13C-1H HMBC technique. The proportion of the regioisomers was found to vary with the substituent on the 1,2,4-triazole thiols. No product corresponding to N4 substitution was isolated from any of the reactions carried out. Copyright
