668969-68-4

Usage

Uses

Used in Pharmaceutical Industry:
Ethyl 2-(5-Bromo-2-fluorophenyl)-2-oxoacetate is used as a versatile reactant for the synthesis of a tricyclic BACE1 inhibitor warhead through β-lactam opening. BACE1 (Beta-secretase 1) is an enzyme involved in the production of amyloid-beta peptides, which are associated with Alzheimer's disease. Ethyl 2-(5-broMo-2-fluorophenyl)-2-oxoacetate plays a crucial role in developing potential therapeutic agents to combat this neurodegenerative disorder.

Upstream product

• 116272-41-4 4-bromo-1-fluoro-2-iodobenzene 
• 95-92-1 oxalic acid diethyl ester 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 668969-67-3 ethyl (5-bromo-2-fluorophenyl)(hydroxy)acetate 

Downstream Products

• 1266785-24-3 (R)-3-amino-3-(5-bromo-2-fluoro-phenyl)-2-methyl-butan-2-ol 
• 1266785-28-7 N-[(R)-1-(5-bromo-2-fluoro-phenyl)-2-hydroxy-1,2-dimethyl-propyl]-2-chloro-acetamide 
• 1266785-30-1 (R)-5-(5-bromo-2-fluoro-phenyl)-5,6,6-trimethyl-morpholin-3-one 
• 1266785-16-3 (R)-5-(5-amino-2-fluoro-phenyl)-5,6,6-trimethyl-morpholine-3-thione 
• 1266785-22-1 (S)-2-methyl-propane-2-sulfinic acid [(R)-1-(5-bromo-2-fluoro-phenyl)-2-hydroxy-1,2-dimethyl-propyl]-amide 
• 1266785-34-5 (R)-5-[5-(benzhydrylidene-amino)-2-fluoro-phenyl]-5,6,6-trimethyl-morpholin-3-one 
• 1266785-21-0 (S)-(5-bromo-2-fluoro-phenyl)-[(Z)-2-methyl-propane-2-sulfinylimino]-acetic acid ethyl ester 
• 1386984-46-8 (R)-2-(5-bromo-2-fluoro-phenyl)-2-hydroxy-3-nitro-propionic acid ethyl ester 
• 1386985-86-9 (R)-3-amino-2-(5-bromo-2-fluoro-phenyl)-2-hydroxy-propionic acid ethyl ester 
• 1386985-87-0 (R)-3-amino-2-(5-bromo-2-fluoro-phenyl)-propane-1,2-diol hydrochloride 
• 1386985-88-1 N-[(R)-2-(5-bromo-2-fluoro-phenyl)-2,3-dihydroxy-propyl]-2-nitro-benzenesulfonamide 
• 1386985-90-5 C₂₀H₂₂BrFN₂O₇S 
• 1386985-89-2 C₂₀H₂₀BrFN₂O₆S 
• 1386985-91-6 C₂₀H₂₀BrFN₂O₆S 

Relevant academic research and scientific papers

OXAZINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF NEUROLOGICAL DISORDERS

The invention relates to novel heterocyclic compounds of the formula (I), in which all of the variables are as defined in the specification, in free form or in pharmaceutically acceptable salt form, to their preparation, to their medical use and to medicaments comprising them.

3-AMINO-5-PHENYL-5,6-DIHYDRO-2H-[1,4]OXAZINES

The present invention relates to 3-Amino-5-phenyl-5,6-dihydro-2H-[1,4]oxazines of formula I having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. T

3-AMINO-5-PHENYL-5,6-DIHYDRO-2H-[1,4]OXAZINE DERIVATIVES

The present invention relates to 3-Amino-5-phenyl-5,6-dihydro-2H-[l,4]oxazine derivatives of formula (I) having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active

ANTIBACTERIAL BENZOIC ACID DERIVATIVES

The invention provides antimicrobial agents and methods of using the agents for sterilization, sanitation, antisepsis, disinfection, and treatment of infections in mammals.