668990-82-7Relevant articles and documents
A 4 - methoxy pyrrole intermediate preparation method
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Paragraph 0025; 0027, (2019/07/10)
The present invention provides 4 - methoxy pyrrole intermediate preparation method, comprises the following steps: (1) of formula (I) compound 2, 4 - difluorobenzaldehyde with formula (II) compound to the [...] sulfonic acid in the alkaline solvent and th
Cycloalkyl-[4-(difluorophenyl)-oxazol-5-yl]-triazolo-pyridines
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Page 21, (2010/02/06)
The present invention relates to novel cycloalkyl-[4-(difluorophenyl)-oxazol-5-yl]triazolo-pyridines, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use. The compounds of the present invention are potent inhibitors of MAP kinases, preferably p38 kinase. They are useful in the treatment of inflammation, osteoarthritis, rheumatoid arthritis, cancer, reperfusion or ischemia in stroke or heart attack, autoimmune diseases and other disorders.