66900-32-1 Usage
General Description
(1S,3S)-3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl (4xi)-2,3,6-trideoxy-3-(L-leucylamino)-alpha-L-threo-hexopyranoside is a complex chemical compound with a long name. It is a tetracycline antibiotic derived from the bacterium Streptomyces spheroides. (1S,3S)-3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl (4xi)-2,3,6-trideoxy-3-(L-leucylamino)-alpha-L-threo-hexopyranoside is used in the treatment of various bacterial infections and works by inhibiting the growth of bacteria. It is a semi-synthetic derivative of tetracycline, and its chemical structure consists of a tetracycline core with additional functional groups and amino sugars, making it effective against a broad spectrum of bacteria.
Check Digit Verification of cas no
The CAS Registry Mumber 66900-32-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,9,0 and 0 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 66900-32:
(7*6)+(6*6)+(5*9)+(4*0)+(3*0)+(2*3)+(1*2)=131
131 % 10 = 1
So 66900-32-1 is a valid CAS Registry Number.
66900-32-1Relevant articles and documents
Amino acid and dipeptide derivatives of daunorubicin. 1. Synthesis, physicochemical properties, and lysosomal digestion
Masquelier,Baurain,Trouet
, p. 1166 - 1170 (2007/10/02)
The synthesis of amino acid and dipeptide derivatives of daunorubicin (DNR) is described. The binding-affinity parameters for DNA of those derivatives were determined by a spectral titration method. The affinity constants of the amino acid and dipeptide derivatives are, respectively, three and ten times lower than that of DNR. The susceptibility of those derivatives toward lysosomal peptidases was studied. It was found that the Leu and the Ala-Leu derivatives are the most rapidly hydrolyzed into DNR. It is concluded that Leu-DNR and Ala-Leu-DNR could act as prodrugs of DNR, which could be activated inside or in the close vicinity of tumor cells which display a high aminopeptidase activity.
