669001-67-6

Basic information

• Product Name: Benzoyl chloride, 3,4-bis(cyclopropylmethoxy)-
• CAS NO: 669001-67-6
• Molecular Formula: C15H17ClO3
• Molecular Weight: 280.751
• Mol File: 669001-67-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzoyl chloride, 3,4-bis(cyclopropylmethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoyl chloride, 3,4-bis(cyclopropylmethoxy)-(669001-67-6)
• EPA Substance Registry System: Benzoyl chloride, 3,4-bis(cyclopropylmethoxy)-(669001-67-6)

Safety Data

• Hazardous Substances Data: 669001-67-6(Hazardous Substances Data)

Upstream product

• 1369851-30-8 3,4-bis(cyclopropylmethoxy)benzoic acid 
• 1369817-76-4 3,4-bis(cyclopropylmethoxy)benzaldehyde 
• 139-85-5 3,4-dihydroxybenzaldehyde 

Downstream Products

• 1391052-24-6 3,4-bis(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl) benzamide 

Relevant articles and documents

Synthesis of an impurity in crude roflumilast

A simple synthetic method has been developed for the synthesis of 3,4-bis(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl) benzamide (an impurity in crude roflumilast) from 3,4-dihydroxybenzaldehyde via alkylation, oxidation, chlorination and acylation reactions. Acetonitrile was used as the solvent in all the three steps for convenient recovery. The oxidation of 3,4-bis(cyclopropylmethoxy)benzaldehyde (purity, 86.2%) by sodium chlorite afforded the corresponding acid with purity of 99.2%. Finally, N-acylation of 3,5-dichloropyridin-4-amine yielded 3,4-bis(cyclopropylmethoxy)-N-(3,5- dichloropyridin-4-yl) benzamide. Without column chromatography, the overall yield of the target compound was about 70%.