669010-41-7

Upstream product

• 669010-39-3 (1S,4S,4aS,5S,6S,8aS)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-6-((E)-2-iodo-1-methyl-vinyl)-4,7-dimethyl-1-triisopropylsilanyloxy-1,2,3,4,4a,5,6,8a-octahydro-naphthalene 
• 669010-37-1 (1S,4S,4aS,5S,6S,8aS)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-6-(1-ethoxy-ethoxymethyl)-4,7-dimethyl-1-triisopropylsilanyloxy-1,2,3,4,4a,5,6,8a-octahydro-naphthalene 
• 669010-40-6 (1S,4S,4aS,5S,6R,8aS)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4,7-dimethyl-6-((E)-1-methyl-propenyl)-1-triisopropylsilanyloxy-1,2,3,4,4a,5,6,8a-octahydro-naphthalene 
• 669010-48-4 (1S,4S,4aS,5S,6R,8aS)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-6-(2,2-dibromo-vinyl)-4,7-dimethyl-1-triisopropylsilanyloxy-1,2,3,4,4a,5,6,8a-octahydro-naphthalene 
• 669010-24-6 (+)-(1S,4S,5S,6R,8aS)-5-(tert-butyl-diphenyl-silanyloxymethyl)-6-ethynyl-4,7-dimethyl-1-triisopropylsilanyloxy-1,2,3,4,4a,5,6,8a-octahydro-naphthalene 
• 669010-38-2 [(1S,2S,4aS,5S,8S,8aS)-1-(tert-Butyl-diphenyl-silanyloxymethyl)-3,8-dimethyl-5-triisopropylsilanyloxy-1,2,4a,5,6,7,8,8a-octahydro-naphthalen-2-yl]-methanol 
• 669010-47-3 (1S,2S,4aS,5S,8S,8aS)-1-(tert-Butyl-diphenyl-silanyloxymethyl)-3,8-dimethyl-5-triisopropylsilanyloxy-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-2-carbaldehyde 
• 669010-35-9 (1S,2S,4aS,5S,8S,8aR)-2-(1-Ethoxy-ethoxymethyl)-3,8-dimethyl-5-triisopropylsilanyloxy-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-1-carboxylic acid methoxy-methyl-amide 
• 669010-36-0 [(1S,2S,4aS,5S,8S,8aS)-2-(1-Ethoxy-ethoxymethyl)-3,8-dimethyl-5-triisopropylsilanyloxy-1,2,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl]-methanol 
• 669010-34-8 (1S,2S,4aS,5S,8S,8aR)-2-Hydroxymethyl-3,8-dimethyl-5-triisopropylsilanyloxy-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-1-carboxylic acid methoxy-methyl-amide 
• 669010-51-9 (1S,4S,4aS,5S,6R,8aS)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-4,7-dimethyl-6-((E)-1-methyl-propenyl)-1,2,3,4,4a,5,6,8a-octahydro-naphthalen-1-ol 
• 669010-50-8 (1S,4S,4aS,5S,6R,8aS)-5-Hydroxymethyl-4,7-dimethyl-6-((E)-1-methyl-propenyl)-1,2,3,4,4a,5,6,8a-octahydro-naphthalen-1-ol 
• 669010-52-0 Benzoic acid (1S,4S,4aS,5S,6R,8aS)-5-(tert-butyl-dimethyl-silanyloxymethyl)-4,7-dimethyl-6-((E)-1-methyl-propenyl)-1,2,3,4,4a,5,6,8a-octahydro-naphthalen-1-yl ester 

Downstream Products

• 669010-42-8 Benzoic acid (1S,4S,4aR,5S,6R,8aS)-5-formyl-4,7-dimethyl-6-((E)-1-methyl-propenyl)-1,2,3,4,4a,5,6,8a-octahydro-naphthalen-1-yl ester 
• 669010-53-1 Benzoic acid (1S,4S,4aS,5S,6R,8aS)-5-((1E,3E)-4-ethoxycarbonyl-buta-1,3-dienyl)-4,7-dimethyl-6-((E)-1-methyl-propenyl)-1,2,3,4,4a,5,6,8a-octahydro-naphthalen-1-yl ester 

Relevant academic research and scientific papers

First Total Synthesis of Antimitotic Compound, (+)-Phomopsidin

(Equation presented) The first total synthesis of (+)-phomopsidin has been achieved via a diastereoselective transannular Diels-Alder (TADA) reaction. Key steps in the synthesis include diastereoselective ynone reduction with (-)-α-pinene and 9-BBN, macrocyclization by E-selective intramolecular Horner-Wadsworth-Emmons (HWE) reaction, as well as carbometalation under Wipf's conditions, followed by HWE reaction at low temperature to selectively construct the (E)-1-methylpropenyl and (1E,2E)-4-carboxy-1,3-butadienyl substituents.