669063-38-1Relevant academic research and scientific papers
P1 and P3 optimization of novel bicycloproline P2 bearing tetrapeptidyl α-ketoamide based HCV protease inhibitors
Victor, Frantz,Lamar, Jason,Snyder, Nancy,Yip, Yvonne,Guo, Deqi,Yumibe, Nathan,Johnson, Robert B.,Wang, Q. May,Glass, John I.,Chen, Shu-Hui
, p. 257 - 261 (2007/10/03)
With the aim of discovering potent and selective HCV protease inhibitors, we synthesized and evaluated a series of 1a based tetrapeptidyl ketoamides with additional modification(s) at P1′, P1, and P3 positions. As a result of this effort, we found that re
