669065-48-9

Upstream product

• 133039-03-9 (3R)-3,4-dihydroxybutyric acid benzyl ester 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 110652-75-0 rac-2-oxiraneacetic acid phenylmethyl ester 

Downstream Products

• 669065-40-1 (R)-4-(tert-butyldimethylsilyloxy)-3-methoxy-butyric acid benzyl ester 
• 669065-53-6 [1(1RS,3Z,5R,6S,7S),3R]-N-{3-[1-benzenesulfonyl-7,9-bis(tert-butyl-dimethylsilyloxy)-4,6-dimethyl-5-triisopropylsilyloxy-non-3-enyl]-2,5-dimethoxy-phenyl}-4-(tert-butyldimethylsilyloxy)-3-methoxy-butyramide 
• 669065-54-7 [1(3Z,5R,6S,7S),3R]-N-{3-[7,9-bis(tert-butyl-dimethylsilyloxy)-4,6-dimethyl-5-triisopropylsilyloxy-non-3-enyl]-2,5-dimethoxy-phenyl}-4-(tert-butyldimethylsilyloxy)-3-methoxy-N-(2,2,2-trichloroethoxymethyl)-butyramide 
• 669065-44-5 [1(3Z,5R,6S,7S),3R]-N-{3-[7,9-bis(tert-butyl-dimethylsilyloxy)-4,6-dimethyl-5-triisopropylsilyloxy-non-3-enyl]-2,5-dimethoxy-phenyl}-4-(tert-butyldimethylsilyloxy)-3-methoxy-butyramide 
• 198757-93-6 (R)-N-(3-benzenesulfonylmethyl-2,5-dimethoxyphenyl)-4-(tert-butyldimethylsilyloxy)-3-methoxybutyramide 

Relevant academic research and scientific papers

A Convergent Synthesis of the Macrocyclic Core of Cytotrienins: Application of RCM for Macrocyclization

(Equation presented) The asymmetric synthesis of the fully elaborated macrocyclic core of cytotrienins A-D, potent apoptosis-inducing agents, is described. Synthetic highlights include the construction of the aniline bond using a copper-mediated amidation and the use of a ring-closing metathesis (RCM) reaction to efficiently install the (E,E,E)-triene and simultaneously construct the macrocyclic lactam.