669082-22-8

Upstream product

• 402958-25-2 (1S,3aR,6aS)-ethyl octahydrocyclopenta[c]pyrrole-1-carboxylate 
• 402958-22-9 (1S,3aR,6aS)-4-Hydroxy-hexahydro-cyclopenta[c]pyrrole-1,2-dicarboxylic acid 2-benzyl ester 1-ethyl ester 
• 402958-23-0 (1S,3aR,6aS)-4-Methylsulfanylthiocarboxyoxy-hexahydro-cyclopenta[c]pyrrole-1,2-dicarboxylic acid 2-benzyl ester 1-ethyl ester 
• 402958-24-1 (1S,3aR,6aS)-Hexahydro-cyclopenta[c]pyrrole-1,2-dicarboxylic acid 2-benzyl ester 1-ethyl ester 
• 669082-20-6 (1S,3aR,6aS)-2-((S)-2-Isopropoxycarbonylamino-3,3-dimethyl-butyryl)-octahydro-cyclopenta[c]pyrrole-1-carboxylic acid ethyl ester 
• 669082-21-7 (1S,3aR,6aS)-2-((S)-2-Isopropoxycarbonylamino-3,3-dimethyl-butyryl)-octahydro-cyclopenta[c]pyrrole-1-carboxylic acid 

Relevant academic research and scientific papers

Novel P4 truncated tripeptidyl α-ketoamides as HCV protease inhibitors

We describe herein the synthesis and evaluation of two series of P-4 truncated tripeptidyl α-ketoamides as HCV serine protease inhibitors. The most promising compound disclosed in this communication 7b demonstrated enzyme binding affinity (Ki)

Synthesis and evaluation of tripeptidyl α-ketoamides as human rhinovirus 3C protease inhibitors

We describe herein the synthesis and biological evaluation of a series of tripeptidyl α-ketoamides as human rhinovirus (HRV) 3C protease inhibitors. The most potent inhibitor discussed in this manuscript, 4I, exhibited impressive enzyme inhibitory activity as well as antiviral activity against HRV-14.