669083-47-0Relevant academic research and scientific papers
Synthesis of a formamidine-protected 5′-amino-2′,5′- dideoxyguanosine phosphoramidite and preparation of 5′- acylamidooligonucleotides
Rojas Stütz, Jan A.,Richert, Clemens
, p. 509 - 513 (2004)
A 5′-amino-2′,5′-dideoxyguanosine phosphoramidite building block for DNA synthesis was prepared from 2-N-(dibutylformamidino)- 2′-deoxyguanosine in four steps and 68% overall yield. Two of the three steps of the conversion from the 5′-alcohol to the monomethoxytritylamine were performed in the same flask.
