669089-83-2

Basic information

• Product Name: Benzoic acid, 3-methoxy-2-[(2-methoxyethoxy)methoxy]-5-(2-propenyl)-, methyl ester
• CAS NO: 669089-83-2
• Molecular Formula: C16H22O6
• Molecular Weight: 310.347
• Mol File: 669089-83-2.mol

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 3-methoxy-2-[(2-methoxyethoxy)methoxy]-5-(2-propenyl)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 3-methoxy-2-[(2-methoxyethoxy)methoxy]-5-(2-propenyl)-, methyl ester(669089-83-2)
• EPA Substance Registry System: Benzoic acid, 3-methoxy-2-[(2-methoxyethoxy)methoxy]-5-(2-propenyl)-, methyl ester(669089-83-2)

Safety Data

• Hazardous Substances Data: 669089-83-2(Hazardous Substances Data)

Upstream product

• 3970-21-6 2-Methoxyethoxymethyl chloride 
• 85614-43-3 2-hydroxy-3-methoxy-5-(2-propeny)benzoic acid, methyl ester 

Downstream Products

• 669089-88-7 (S)-N-[(1-allyl-2-pyrrolidinyl)methyl]-3-methoxy-2-[(2-methoxyethoxy)methoxy]-5-(3-fluoropropyl)benzamide 
• 669089-85-4 3-methoxy-2-[(2-methoxyethoxy)methoxy]-5-(3-[[(4-methylphenyl)sulfonyl]oxy]propyl)benzoic acid methyl ester 
• 669089-89-8 (S)-N-[(1-allyl-2-pyrrolidinyl)methyl]-2-hydroxy-3-methoxy-5-(3'-fluoropropyl)benzamide 
• 669089-87-6 3-methoxy-2-[(2-methoxyethoxy)methoxy]-5-(3-fluoropropyl)benzoic acid 
• 669089-86-5 3-methoxy-2-[(2-methoxyethoxy)methoxy]-5-(3-fluoropropyl)benzoic acid methyl ester 
• 669089-90-1 2-hydroxy-3-methoxy-5-(3-fluoropropyl)benzoic acid 
• 669089-84-3 3-methoxy-2-[(2-methoxyethoxy)methoxy]-5-(3-hydroxypropyl)benzoic acid methyl ester 

Relevant articles and documents

11C-Fallypride: Radiosynthesis and preliminary evaluation of a novel dopamine D2/D3 receptor PET radiotracer in non-human primate brain

Fallypride [benzamide, 5-(3-fluoropropyl)-2,3-dimethoxy-N-[(2S)-1-(2- propenyl)-2-pyrrolidinyl]methyl]-, CAS RN 166173-78-0] is a selective dopamine D2/D3 receptor antagonist. Carbon-11 labeled fallypride may serve as a radiotracer for use in biomedical imaging technique positron emission tomography (PET). The precursor, 5-(3-fluoropropyl)-2-hydroxy-3-methoxy-N-[(2S)- 1-(2-propenyl)-2-pyrrolidinyl]methyl]benzamide was synthesized from 2-hydroxy-3-methoxy-5-(2-propenyl)benzoic acid, methyl ester in seven steps with approximately 10% overall chemical yield. Using this precursor 11C-fallypride was produced by radiolabeling with 11C-methyl iodide in 25-40% radiochemical yields with specific activities of 200-1000 Ci/mmol. PET imaging studies in nonhuman primates with 11C-fallypride showed radiotracer localization in dopaminergic brain regions such as caudate, putamen, thalamus and cortex. This regional localization of 11C-fallypride is similar to that observed previously for 18F-fallypride. The results suggest 11C-fallypride is a useful PET radiotracer for imaging dopamine D2/ D3 receptors.