66912-26-3Relevant academic research and scientific papers
Dibenzazepine-linked isoxazoles: New and potent class of α-glucosidase inhibitors
Umm-E-Farwa,Ullah, Saeed,Khan, Maria Aqeel,Zafar, Humaira,Atia-tul-Wahab,Younus, Munisaa,Choudhary, M. Iqbal,Basha, Fatima Z.
, (2021/05/10)
α-Glucosidase inhibition is a valid approach for controlling hyperglycemia in diabetes. In the current study, new molecules as a hybrid of isoxazole and dibenzazepine scaffolds were designed, based on their literature as antidiabetic agents. For this, a series of dibenzazepine-linked isoxazoles (33–54) was prepared using Nitrile oxide-Alkyne cycloaddition (NOAC) reaction, and evaluated for their α-glucosidase inhibitory activities to explore new hits for treatment of diabetes. Most of the compounds showed potent inhibitory potency against α-glucosidase (EC 3.2.1.20) enzyme (IC50 = 35.62 ± 1.48 to 333.30 ± 1.67 μM) using acarbose as a reference drug (IC50 = 875.75 ± 2.08 μM). Structure-activity relationship, kinetics and molecular docking studies of active isoxazoles were also determined to study enzyme-inhibitor interactions. Compounds 33, 40, 41, 46, 48–50, and 54 showed binding interactions with critical amino acid residues of α-glucosidase enzyme, such as Lys156, Ser157, Asp242, and Gln353.
Design and synthesis of spiro derivatives of parthenin as novel anti-cancer agents
Reddy, Doma Mahendhar,Qazi, Naveed A.,Sawant, Sanghpal D.,Bandey, Abid H.,Srinivas, Jada,Shankar, Mannepalli,Singh, Shashank K.,Verma, Monika,Chashoo, Gousia,Saxena, Arpita,Mondhe, Dilip,Saxena, Ajit K.,Sethi,Taneja, Subhash C.,Qazi, Gulam N.,Sampath Kumar
body text, p. 3210 - 3217 (2011/07/31)
Several novel spiro derivatives of parthenin (1) have been synthesized by the dipolar cycloaddition using various dipoles viz; benzonitrile oxides, nitrones and azides with exocyclic double bond of C ring (α-methylene- γ-butyrolactone). Majority of the compounds exhibited improved anti-cancer activity compared to the parthenin, when screened for their in vitro cytotoxicity against three human cancer cell lines viz., SW-620, DU-145 and PC-3. In vivo screening of select analog revealed improved anti-cancer activity with low mammalian toxicity as compared to parthenin. The results of the cytotoxicity pattern of these derivatives reveals the SAR of these sesquiterpinoid lactones and possible role of α,β-unsaturated ketone of parthenin in inhibiting NF-kB. A mechanistic correlation of anti-cancer activity along with in vivo and western blotting experiments has been described.
N-Heterocyclic carbene-catalyzed 1,3-dipolar cycloaddition reactions: A facile synthesis of 3,5-di- and 3,4,5-trisubstituted isoxazoles
Kankala, Shravankumar,Vadde, Ravinder,Vasam, Chandra Sekhar
, p. 7869 - 7876 (2011/12/05)
A first example of organo-N-heterocyclic carbene (NHC) catalyzed click-type fast 1,3-dipolar cycloaddition of nitrile oxides with alkynes was developed for the regioselective synthesis of 3,5-di- and 3,4,5-trisubstituted isoxazoles. Triethylamine (Et
Reaction of allenylmagnesium and allenylindium bromides with nitrile oxides: synthesis of novel 5-butynyl- and 5-methylisoxazoles
Sampath Kumar,Singh, Parvinder Pal,Shafi, Syed,Reddy, Pitta Bhaskar,Shravankumar, Kankala,Reddy, Doma Mahender
, p. 887 - 890 (2007/10/03)
5-Butynylisoxazoles were obtained in high yields through a domino addition, C-O heterocyclization involving allenylmagnesium bromide and benzonitrile oxide in dry THF, in which the corresponding 5-methylisoxazoles were isolated in trace amounts. However, when the reactions were attempted in aqueous media using allenylindium bromide, 5-methylisoxazoles were formed as the sole products in high yields.
Reaction of β-keto ethyleneacetals with hydroxylamine: A correction
Paradkar,Latham,Krishnaswami
, p. 1497 - 1500 (2007/10/02)
A reaction of 2-(2-nitrobenzoylmethyl)-1,3-dioxolane (3) with hydroxylamine, followed by acid catalyzed cyclization, produced 5-(2- nitrophenyl)isoxazole (5) as the only isolable product, whereas 2- (benzoylmethyl)-1,3-dioxolane (9) under identical condit
Unusual Chemo- and Stereo-selectivities in the rEactions of 1,2-Dichlorocyclopenes with Nitrile Oxides
Baird, Mark S.,Li, Xiaoming,Dulayymi, Juma'a R. Al,Kurdjukov, Alexader I.,Pavlov, Valery A.
, p. 2507 - 2508 (2007/10/02)
1,2-Dichloro-3,3-dimethylcyclopropene reacts with a number of nitrile oxides to produce oxazines in moderate to good yield in a reaction which apparently involves an unusual formal 3-centre plus 3-centre cycloaddition of the dipole to an intermediate viny
Mechanism of Reaction of Isomeric Nitrolic Acids to Nitrile Oxides in Aqueous Solution
Egan, Carmel,Clery, Maurice,Hegarty, Anthony F.,Welch, Alan J.
, p. 249 - 256 (2007/10/02)
Both E and Z isomers of acetonitrolic acids 15 and 16 can be prepared when the OH group is protected by acetylation.Photoisomerization of the E-isomer resulted in quantitative conversion into the pure Z-isomer 16.Hydrolysis of the E-isomer 15 produced the parent nitrolic acid 14 which undergoes loss of NO2(1-) from the conjugate base at high pH.This reaction is however relatively slow suggesting base solubility and acidic reprecipitation as a method of purification of E-nitrolic acids.Deprotection of (Z)-O-acetylacetonitrolic acid by HO(1-) gives a highly reactive Z-nitrolic acid 17 which undergoes loss of NO2(1-) at a rate which precludes its detection; however the subsequent reactions of acetonitrile oxide (CH3CNO) formed were monitored.Rapid loss of NO2(1-) therefore occurs when there is assistance from an antiperiplanar lone pair on the imino nitrogen of the oximate anion.Arylnitrolic acids were also examined; these were in the E configuration 26 and therefore underwent slow loss of NO2(1-).Since NMR and IR data are unreliable for the assignment of configuration of nitrolic acids (relative to other oximes) a single crystal diffraction study was carried out on E-acetonitrolic acid 14.The large difference in reactivity observed for the E- and Z-nitrolic acids now permits strong supporting evidence for structural assignments.
