66922-70-1

Basic information

• Product Name: 3'-Methoxy-α,α,4'-trihydroxyacetophenone
• Synonyms: 3'-Methoxy-α,α,4'-trihydroxyacetophenone;2,2,4'-Trihydroxy-3'-Methoxy-acetophenone;2,2-Dihydroxy-1-(4-hydroxy-3-Methoxyphenyl)-ethanone
• CAS NO: 66922-70-1
• Molecular Formula: C9H10O5
• Molecular Weight: 198.173
• Product Categories: Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 66922-70-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 387.9°C at 760 mmHg
• Flash Point: 158.8°C
• Appearance: /
• Density: 1.427g/cm³
• Vapor Pressure: 1.04E-06mmHg at 25°C
• Refractive Index: 1.606
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility: Dichloromethane, Dimethyl Sulfoxide, Methanol
• CAS DataBase Reference: 3'-Methoxy-α,α,4'-trihydroxyacetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-Methoxy-α,α,4'-trihydroxyacetophenone(66922-70-1)
• EPA Substance Registry System: 3'-Methoxy-α,α,4'-trihydroxyacetophenone(66922-70-1)

Safety Data

• Hazardous Substances Data: 66922-70-1(Hazardous Substances Data)

Usage

Chemical Properties

Orange Solid

Uses

Shows central nervous system depressant activity.

InChI:InChI=1/C9H10O5/c1-14-7-4-5(2-3-6(7)10)8(11)9(12)13/h2-4,9-10,12-13H,1H3

Upstream product

• 32025-66-4 3-methoxy-4-hydroxyphenylglyoxal 
• 498-02-2 1-(3-methoxy-4-hydroxyphenyl)ethanone 

Relevant articles and documents

Synthesis of 4-Hydroxy-3-(2-arylimidazo[1,2-a]pyridin-3-yl)quinolin-2(1H)-ones in the Presence of DABCO as an Efficient Organocatalyst

The one-pot, three-component, synthesis of a new series of 4-hydroxy-3-(2-arylimidazo[1,2-a]pyridin-3-yl)quinolin-2(1H)-ones in the presence of DABCO as a catalyst has been achieved using aryl glyoxal monohydrates, quinoline-2,4(1H,3H)-dione, and 2-aminopyridine in H2O/EtOH under reflux conditions. The cheapness of organocatalyst, simple workup, operational simplicity, regioselectivity, and high yields are some advantages of this protocol.

An efficient synthesis of imidazo[2,1-b][1,3,4]thiadiazol-7-ium hydroxides by a one-pot, three-component reaction in water

An improved synthesis of 2-ethyl-5-(2-hydroxy-4-oxoquinolin-3(4H)-ylidene)-6-aryl-5,6-dihydroimidazo[2,1-b][1,3,4]thiadiazol-7-ium hydroxide derivatives 4a-k via the reaction of aryl glyoxal monohydrates 1a-k, quinoline-2,4-diol 2 and 2-amino-[1,3,4]thiadiazole (3) in the presence of Et3N/sulfamic acid in H2O is described. This green protocol is characterized by the use of the readily available catalyst and reactants, short reaction times, operational simplicity and high yields of products. The structures of all compounds were characterized by 1H NMR, 13C NMR and Fourier-transform infrared (FT-IR) spectral data and microanalyses.

The catalyst-free syntheses of pyrazolo[3,4-b]quinolin-5-one and pyrazolo[4′,3′:5,6]pyrido[2,3-d]pyrimidin-5,7-dione derivatives by one-pot, three-component reactions

Herein we report the syntheses of pyrazolo[3,4-b]quinolin-5-one and pyrazolo[4′,3′:5,6]pyrido[2,3-d]pyrimidin-5,7-dione derivatives by cyclocondensation of 1,3-diketones, 3-methyl-1-phenyl-1H-pyrazole-5-amine and arylglyoxals, under catalyst-free conditions in H2O/EtOH at reflux in 65–98% and 73–96% yields respectively. This protocol provides mild reaction conditions, good to high yields, non-catalytic, simple procedures and easy isolation of products to structurally diverse tricyclic pyrazolo[3,4-b]quinolin-5-one and pyrazolo[4′,3′:5,6]pyrido[2,3-d]pyrimidin-5,7-dione derivatives, which may have biological and pharmacological activities.