66947-32-8

Basic information

• Product Name: Glycine, N-(2,4-dimethylphenyl)-
• Synonyms: OTAVA-BB 1142623;N-2,4-Xylylglycine;N-(2,4-Dimethylphenyl)glycine;Glycine, N-(2,4-dimethylphenyl)-;(2,4-DIMETHYLANILINO)ACETIC ACID;2-[(2,4-dimethylphenyl)amino]acetic acid
• CAS NO: 66947-32-8
• Molecular Formula: C₁₀H₁₃NO₂
• Molecular Weight: 179.22
• Mol File: 66947-32-8.mol
• Article Data: 2

Chemical Properties

• Melting Point: 144-145℃
• Appearance: /
• Density: 1.174
• CAS DataBase Reference: Glycine, N-(2,4-dimethylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Glycine, N-(2,4-dimethylphenyl)-(66947-32-8)
• EPA Substance Registry System: Glycine, N-(2,4-dimethylphenyl)-(66947-32-8)

Safety Data

• Hazardous Substances Data: 66947-32-8(Hazardous Substances Data)

Usage

General Description

Glycine, N-(2,4-dimethylphenyl)-, also known as 2,4-dimethylphenylglycine, is a chemical compound belonging to the class of amino acids. It is derived from the amino acid glycine and has a molecular formula of C10H13NO2. Glycine, N-(2,4-dimethylphenyl)- is commonly used in the pharmaceutical and chemical industries as a building block for the synthesis of various compounds, including pharmaceutical drugs and agricultural chemicals. It is also used as a chiral auxiliary in asymmetric synthesis and as a ligand in metal-catalyzed reactions. 2,4-dimethylphenylglycine has been identified as a potential key intermediate in the production of various pharmaceuticals and agrochemicals, making it an important compound in the field of organic chemistry.

Upstream product

• 79-11-8 chloroacetic acid 
• 95-68-1 2,4-Xylidine 
• 7732-18-5 water 

Downstream Products

• 299928-38-4 N-acetyl (2,4-dimethyl phenyl)-glycine 
• 91513-39-2 bis(2,4-dimethylphenylglycinate)Zn(II) 
• 99193-27-8 bis(N-(2,4-dimethylphenyl)glycinato) palladium(II) 
• 104412-20-6 N-(2,4-dimethyl-phenyl)-N-nitroso-glycine 
• 17711-27-2 3-(2,4-dimethylphenyl)sydnone 

Relevant articles and documents

Identification of a Water-Soluble Indirubin Derivative as Potent Inhibitor of Insulin-like Growth Factor 1 Receptor through Structural Modification of the Parent Natural Molecule

Indirubins have been identified as potent ATP-competitive protein kinase inhibitors. Structural modifications in the 5-and 3′-position have been extensively investigated, but the impact of substituents in 5′-position is not equally well-studied. Here, we report the synthesis of new indirubin 3′-and 5′-derivatives in the search of water-soluble indirubins by introducing basic centers. Antiproliferative activity of all compounds in tumor cells was evaluated along with kinase inhibition of selected compounds. The results show the 3′-position to tolerate large substituents without compromising activity, whereas bulk and rigid substituents in 5′-position appear unfavorable. Screening molecular targets of water-soluble 3′-oxime ethers revealed 6ha as preferential inhibitor of insulin-like growth factor 1 receptor (IGF-1R) in a panel of 22 protein kinases and in cells. Consistently, 6ha inhibited tumor cell growth in the NCI 60 cell line panel and induced apoptosis. The results indicate that the 5′-position provides limited space for chemical modifications and identify 6ha as a potent water-soluble indirubin-based IGF-1R inhibitor.