66947-32-8

Usage

Uses

Used in Pharmaceutical Industry:
Glycine, N-(2,4-dimethylphenyl)is used as a building block for the synthesis of various pharmaceutical drugs. Its unique structure allows it to be incorporated into the development of new medications, potentially leading to the creation of innovative treatments for various diseases and conditions.
Used in Chemical Industry:
In the chemical industry, Glycine, N-(2,4-dimethylphenyl)is used as a building block for the synthesis of agricultural chemicals. Its versatile structure enables it to be a key component in the development of new agrochemicals, which can contribute to more effective and sustainable agricultural practices.
Used as a Chiral Auxiliary:
Glycine, N-(2,4-dimethylphenyl)is used as a chiral auxiliary in asymmetric synthesis. Its unique properties allow it to be an essential component in the synthesis of enantiomerically pure compounds, which are crucial in various applications, including pharmaceuticals and agrochemicals.
Used as a Ligand in Metal-Catalyzed Reactions:
Glycine, N-(2,4-dimethylphenyl)is also used as a ligand in metal-catalyzed reactions. Its ability to coordinate with metal centers makes it a valuable component in the development of new catalytic systems, which can lead to more efficient and selective chemical transformations.

Upstream product

• 79-11-8 chloroacetic acid 
• 95-68-1 2,4-Xylidine 
• 7732-18-5 water 

Downstream Products

• 91513-39-2 bis(2,4-dimethylphenylglycinate)Zn(II) 
• 299928-38-4 N-acetyl (2,4-dimethyl phenyl)-glycine 
• 99193-27-8 bis(N-(2,4-dimethylphenyl)glycinato) palladium(II) 
• 104412-20-6 N-(2,4-dimethyl-phenyl)-N-nitroso-glycine 
• 17711-27-2 3-(2,4-dimethylphenyl)sydnone 

Relevant academic research and scientific papers

Identification of a Water-Soluble Indirubin Derivative as Potent Inhibitor of Insulin-like Growth Factor 1 Receptor through Structural Modification of the Parent Natural Molecule

Indirubins have been identified as potent ATP-competitive protein kinase inhibitors. Structural modifications in the 5-and 3′-position have been extensively investigated, but the impact of substituents in 5′-position is not equally well-studied. Here, we report the synthesis of new indirubin 3′-and 5′-derivatives in the search of water-soluble indirubins by introducing basic centers. Antiproliferative activity of all compounds in tumor cells was evaluated along with kinase inhibition of selected compounds. The results show the 3′-position to tolerate large substituents without compromising activity, whereas bulk and rigid substituents in 5′-position appear unfavorable. Screening molecular targets of water-soluble 3′-oxime ethers revealed 6ha as preferential inhibitor of insulin-like growth factor 1 receptor (IGF-1R) in a panel of 22 protein kinases and in cells. Consistently, 6ha inhibited tumor cell growth in the NCI 60 cell line panel and induced apoptosis. The results indicate that the 5′-position provides limited space for chemical modifications and identify 6ha as a potent water-soluble indirubin-based IGF-1R inhibitor.

Synthesis and evaluation of phenyl substituted sydnones as potential DPPH-radical scavengers

A series of phenyl substituted sydnones has been synthesized and their radical-scavenging activity has been studied on DPPH free radical. Out of eighteen compounds screened, nine compounds show interesting activity. A mechanism is presented whereby sydnones scavenge DPPH radical through donating H-atom at 4th-position. Its strong radical-scavenging activity mainly arises from 1, 2, 3-oxadiazolium-5-olate ring. Different substituents and their positions on the phenyl ring differently influence DPPH scavenging activity and therefore, may provide clues to design and develop better free-radical scavenging sydnones with multiple activities.