66953-48-8

Basic information

• Product Name: 5-(prop-2-yn-1-ylthio)-3-(p-tolyl)-1H-1,2,4-triazole
• Synonyms: 5-(prop-2-yn-1-ylthio)-3-(p-tolyl)-1H-1,2,4-triazole
• CAS NO: 66953-48-8
• Molecular Weight: 229.305
• Mol File: 66953-48-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-(prop-2-yn-1-ylthio)-3-(p-tolyl)-1H-1,2,4-triazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(prop-2-yn-1-ylthio)-3-(p-tolyl)-1H-1,2,4-triazole(66953-48-8)
• EPA Substance Registry System: 5-(prop-2-yn-1-ylthio)-3-(p-tolyl)-1H-1,2,4-triazole(66953-48-8)

Safety Data

• Hazardous Substances Data: 66953-48-8(Hazardous Substances Data)

Upstream product

• 64310-34-5 5-(4-methylphenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione 
• 106-96-7 propargyl bromide 
• 64310-34-5 3-p-tolyl-1H-1,2,4-triazole-5-thiol 

Downstream Products

• 77796-48-6 5-Propa-1,2-dienylsulfanyl-3-p-tolyl-1H-[1,2,4]triazole 
• 66894-15-3 6-methyl-2-(4-methylphenyl)[1,3]thiazolo[3,2-b][1,2,4]triazole 

Relevant articles and documents

First regioselective iodocyclization reaction of 3-aryl-5-(prop-2-ynylthio)-1H-1,2,4-triazoles

The regioselective iodocyclization reaction of 3-aryl-5-(prop-2-ynylthio)-1H-1,2,4-triazoles is described for the first time. The iodocyclization reaction of 3-aryl-5-(prop-2-ynylthio)-1H-1,2,4-triazoles using molecular iodine afforded diiodo-compound which on CuI-catalyzed intramolecular C-N coupling reaction gave six-membered 2-aryl-5H-[1,2,4]triazolo[5,1-b][1,3]thiazines, whereas, the five membered 3-aryl-5,6-dihydrothiazolo[2,3-c][1,2,4]triazoles were obtained exclusively when the iodocyclization reaction of 3-aryl-5-(prop-2-ynylthio)-1H-1,2,4-triazoles was carried out using NIS.

Sodium Hydroxide: A Mild and Inexpensive Catalyst for the Regioselective Synthesis of 2-Substituted 5-Methylthiazolo[3,2-A]-s-triazoles

The facile and regioselective synthesis of 2-substituted 5-methylthiazolo[3,2-b]-s-triazoles has been performed by the catalytic action of NaOH on 3-propynylthio-s-triazoles.