66955-76-8

Basic information

• Product Name: 1-(4-Amino-3,5-dichloro-phenyl)-acetic acid
• Synonyms: 1-(4-Amino-3,5-dichloro-phenyl)-acetic acid;(4-Amino-3,5-dichloro-phenyl)-acetic acid
• CAS NO: 66955-76-8
• Molecular Formula: C₈H₇Cl₂NO₂
• Molecular Weight: 220.05
• Mol File: 66955-76-8.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(4-Amino-3,5-dichloro-phenyl)-acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-Amino-3,5-dichloro-phenyl)-acetic acid(66955-76-8)
• EPA Substance Registry System: 1-(4-Amino-3,5-dichloro-phenyl)-acetic acid(66955-76-8)

Safety Data

• Hazardous Substances Data: 66955-76-8(Hazardous Substances Data)

Usage

General Description

1-(4-Amino-3,5-dichloro-phenyl)-acetic acid, also known as diclofenac, is a nonsteroidal anti-inflammatory drug (NSAID) that is commonly used to relieve pain and reduce inflammation. It works by inhibiting the production of certain chemical messengers in the body that cause pain and inflammation. Diclofenac is frequently used to treat conditions such as arthritis, migraines, and menstrual cramps. It can be administered orally or topically and is available in various forms including tablets, capsules, and gels. While diclofenac is generally well-tolerated, it can cause side effects such as stomach upset, heartburn, and dizziness in some individuals. It is important to use diclofenac as directed by a healthcare professional to minimize the risk of adverse effects.

Upstream product

• 1258845-93-0 (4-amino-3,5-dichlorophenyl)acetic acid ethyl ester 

Downstream Products

• 1258845-87-2 2-(4-tert-butylbenzyl)-3-[2-(4-amino-3,5-dichlorophenyl)acetamido]propyl pivalate 
• 1092504-43-2 C₃₅H₄₁Cl₂N₇O₃ 
• 1092504-36-3 C₃₄H₄₀Cl₂N₆O₂ 
• 1092504-72-7 C₁₄H₁₅Cl₂N₃O₂*ClH 
• 1092504-71-6 C₁₃H₁₇Cl₂N₃O*ClH 
• 1092504-66-9 C₁₃H₁₄Cl₂N₂O*ClH 
• 1092067-93-0 C₃₃H₃₈Cl₂N₆O₄ 
• 1092069-63-0 C₁₃H₁₄Cl₂N₂O 
• 1092170-36-9 C₁₂H₁₆Cl₂N₂ 
• 1092069-69-6 C₁₄H₁₅Cl₂N₃O₂ 
• 1092069-62-9 C₁₂H₁₆Cl₂N₂*ClH 
• 1092069-68-5 C₁₃H₁₇Cl₂N₃O 
• 1092069-61-8 C₁₂H₁₄Cl₂N₂O 

Relevant articles and documents

Halogenation of 4-hydroxy/amino-3-methoxyphenyl acetamide TRPV1 agonists showed enhanced antagonism to capsaicin

As an extension of our analysis of the effect of halogenation on thiourea TRPV1 agonists, we have now modified selected 4-hydroxy(or 4-amino)-3- methoxyphenyl acetamide TRPV1 agonists by 5- or 6-halogenation on the aromatic A-region and evaluated them for potency for TRPV1 binding and regulation and for their pattern of agonism/antagonism (efficacy). Halogenation shifted the functional activity at TRPV1 toward antagonism with a greater extent of antagonism as the size of the halogen increased (I > Br > Cl), as previously observed for the thiourea series. The extent of antagonism was greater for halogenation at the 5-position than at the 6-position, in contrast to SAR for the thiourea series. In this series, compounds 55 and 75 showed the most potent antagonism, with Ki (ant) = 2.77 and 2.19 nM, respectively, on rTRPV1 expressed in Chinese hamster ovary cells. The compounds were thus ca. 40-60-fold more potent than 6′-iodononivamide.