66960-27-8

Upstream product

• 18942-46-6 N-(tert-butyloxycarbonyl)-S-(4-methoxybenzyl)cysteine 
• 61884-48-8 Boc-L-Cys(Meb)-OSu 

Downstream Products

• 66960-30-3 Boc-Phe-Cys(MBzl)-NH₂ 
• 191166-58-2 N-t-butoxycarbonyl-S-4-methoxybenzyl-L-cysteine thioamide 
• 185141-49-5 [(S)-2-[(S)-2-((S)-1-Benzyl-2-{(S)-2-[(R)-1-carbamoyl-2-(4-methoxy-benzylsulfanyl)-ethylcarbamoyl]-pyrrolidin-1-yl}-2-oxo-ethylcarbamoyl)-pyrrolidin-1-yl]-1-(4-hydroxy-benzyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester 
• 185141-50-8 [(S)-2-((S)-2-{(S)-1-[(R)-1-Carbamoyl-2-(4-methoxy-benzylsulfanyl)-ethylcarbamoyl]-2-phenyl-ethylcarbamoyl}-pyrrolidin-1-yl)-1-(4-hydroxy-benzyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester 
• 185141-45-1 ((S)-1-Benzyl-2-{(S)-2-[(R)-1-carbamoyl-2-(4-methoxy-benzylsulfanyl)-ethylcarbamoyl]-pyrrolidin-1-yl}-2-oxo-ethyl)-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

A tetrameric enkephalin analog for the putative multivalent interaction with opioid receptors

Based on increased affinity and selectivity of dimeric enkephalin analogs for opioid receptors, divalent interactions have been demonstrated between opioid peptides and receptors. To explore the receptor multivalency suggested by fluorescent microscopic s

Synthesis of a fragment a derivative of an antibiotic, nosiheptide

Two 4-ethoxycarbonyl thiazoyly groups were introduced into 2- and 5- positions of 3-hydroxypyridine in 8 steps using 5-cyano-3-hydroxypyridine (2) as the starting material. The pyridine derivative obtained in the last step was converted to a fragment. A derivative (21) by stepwise introduction of the 2-substituted 4-thiazolyl group into the 6-position. The total yield for the formation of 21 via 14 steps was 7.6%.

Exclusive affinity-labeling of μ opioid receptors by morphiceptin analogs containing S-(3-nitro-2-pyridylthio)cysteine

The S-(3-nitro-2-pyridylthio) (Npys) group only reacts with a free mercapto group to form a disulfide bond. A series of morphiceptin analogs containing SNpys-cysteine were designed and synthesized for specific affinity-labeling of μ opioid receptors. Affi