66962-64-9

Upstream product

• 21715-90-2 N-hydroxy-5-norbornene-2,3-dicarboximide 
• 54515-39-8 3-benzyloxycarbonylamino-2-(S)-hydroxypropionic acid 

Downstream Products

• 66962-65-0 1,2',6',3''-N-benzyloxycarbonyl-4-N-(D,L-3-amino-2-hydroxypropanoyl)fortimicin B 
• 66962-74-1 C₅₂H₆₄N₆O₁₆ 

Relevant academic research and scientific papers

4-N-acylfortimicins B and the preparation of fortimicin A from fortimicin B.

Selective 4-N-acylation of fortimicin B (2) has been accomplished by 4-N-acylation of 1,2',6'-tri-N-benzyloxycarbonylfortimicin B (4) followed by hydrogenolysis of the N-protecting benzyloxycarbonyl groups. In this manner, fortimicin B was converted into fortimicin A (1), and a series of 4-N-acylfortimicins B (3) was prepared for antibacterial assay. The key intermediate, 1,2',6'-tri-N-benzyloxycarbonylfortimicin B, was prepared either directly from fortimicin B or by converting fortimicin A into 1,2',6',2''-tetra-N-benzyloxycarbonylfortimicin A (6a), followed by selective hydrolysis of the 4-N-(N-benzyloxycarbonyl)glycyl group of the latter.