6697-96-7 Usage
Description
2,6-Dichlorobenzenesulfonic acid, also known as 2,6-dichlorobenzenesulfonic acid hydrate, is an organic compound with the chemical formula C6H4Cl2SO3H. It is a white crystalline solid that is soluble in water and has a strong acidic character. The presence of two chlorine atoms at the 2,6-positions on the benzene ring and a sulfonic acid group provides unique chemical properties and reactivity, making it a versatile building block in organic synthesis.
Uses
Used in Pharmaceutical Industry:
2,6-Dichlorobenzenesulfonic acid is used as a key intermediate in the synthesis of various pharmaceutical compounds, particularly in the preparation of pyrazolopyrimidines. These pyrazolopyrimidines act as cyclin-dependent kinase inhibitors, which are important for the development of drugs targeting cancer treatment. The cyclin-dependent kinase inhibitors can help regulate cell cycle progression and prevent the uncontrolled growth of cancer cells.
In the synthesis of pyrazolopyrimidines, 2,6-dichlorobenzenesulfonic acid serves as a starting material, which can be further modified and functionalized to form the desired bioactive molecules. The unique reactivity of the chlorine atoms and the sulfonic acid group allows for various chemical reactions, such as nucleophilic substitution, electrophilic aromatic substitution, and coupling reactions, to be performed efficiently.
Overall, 2,6-dichlorobenzenesulfonic acid plays a crucial role in the development of new pharmaceutical agents, particularly in the area of cancer therapy. Its unique chemical properties and reactivity make it a valuable building block in the synthesis of cyclin-dependent kinase inhibitors and other bioactive compounds with potential therapeutic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 6697-96-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,6,9 and 7 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 6697-96:
(6*6)+(5*6)+(4*9)+(3*7)+(2*9)+(1*6)=147
147 % 10 = 7
So 6697-96-7 is a valid CAS Registry Number.
6697-96-7Relevant articles and documents
Comparison of N,N′-diarylsquaramides and N,N′-diarylureas as antagonists of the CXCR2 chemokine receptor
McCleland, Brent W.,Davis, Roderick S.,Palovich, Michael R.,Widdowson, Katherine L.,Werner, Michelle L.,Burman, Miriam,Foley, James J.,Schmidt, Dulcie B.,Sarau, Henry M.,Rogers, Martin,Salyers, Kevin L.,Gorycki, Peter D.,Roethke, Theresa J.,Stelman, Gary J.,Azzarano, Leonard M.,Ward, Keith W.,Busch-Petersen, Jakob
, p. 1713 - 1717 (2007/10/03)
N,N′-diarylsquaramides were prepared and evaluated as antagonists of CXCR2. The compounds were found to be potent and selective antagonists of CXCR2. Significant differences in SAR was observed relative to the previously described N,N′-diarylurea series. As was the case in the N,N′-diarylurea series, placing sulfonamide substituent adjacent to the acidic phenol significantly reduced the clearance in rat pharmacokinetic studies.
