669718-29-0

Upstream product

• 934-32-7 1H-benzimidazol-2-amine 
• 459-57-4 4-fluorobenzaldehyde 
• 504-02-9 1,3-cylohexanedione 

Relevant academic research and scientific papers

A new type of SO3H-functionalized magnetic-titania as a robust magnetically-recoverable solid acid nanocatalyst for multi-component reactions

SO3H-functionalized magnetic-titania nanoparticles (Fe3O4@TDI@TiO2-SO3H) have been synthesized by a two-step procedure, involving the covalent grafting of n-TiO2 to n-Fe3O4via 2,4-toluene diisocyanate as a regioselective linker (n-Fe3O4@TDI@TiO2) and subsequent sulfonation using chlorosulfonic acid. The as-prepared nanocatalyst was characterized by Fourier transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM) and vibrating sample magnetometry (VSM). The catalytic activity of the nanocatalyst was assessed for the synthesis of benzimidazoquinazolinones and polyhydroquinolines, in which the reaction conditions were optimized by applying central composite design (CCD) through response surface methodology. The nanocatalyst could be separated from the reaction mixture easily by magnetic decantation and reused at least six times without a noticeable degradation in catalytic activity. To the best of our knowledge, there are no literature reports on applying experimental design to optimize the reaction conditions for benzimidazoquinazolinones synthesis.

Catalyst, system and method for achieving simple and convenient catalytic preparation of benzimidazo [2, 1-b] quinolin-6-one derivative

The invention discloses a catalyst, a system and a method for achieving simple and convenient catalytic preparation of a benzimidazo [2, 1-b] quinolin-6-one derivative, and belongs to the technical field of preparation of chemical materials. The system comprises a reaction container, a microwave reactor, a suction filtration device, a washing device and a drying device. Aromatic aldehyde, 1, 3-cyclohexanedione and 2-aminobenzimidazole are used as reactive raw materials, and through selection of specific functionalized ionic liquid as a catalyst and in a microwave-assisted heating reaction way, the utilization rate of the raw materials and the yield rate of the obtained product can be effectively increased; the catalyst is relatively small in using amount, good in recycling performance and low in preparation cost and is conveniently produced industrially on a large scale.

Green and high efficient synthesis of triaza-benzo[b]fluoren-6-one derivatives in water under microwave irradiation

(Chemical Equation Presented) Triaza-benzo[b]fluoren-6-one derivatives were synthesized via the three-component reaction of aldehyde, cyclohexane-1,3-dione compound and 2-aminobenzimidazole in water under microwave irradiation. The new protocol has the advantages of excellent yield, low cost, reduced environment impact, wide scope and convenient procedure.