669770-71-2Relevant academic research and scientific papers
Alkylation of Allyl/Alkenyl Sulfones by Deoxygenation of Alkoxyl Radicals
Han, Jia-Bin,Guo, Ao,Tang, Xiang-Ying
supporting information, p. 2989 - 2994 (2019/02/05)
A challenging deoxygenation of alkoxyl radicals from readily accessible alcohol derivatives was developed, affording facile synthesis of functionalized alkenes with good functional group tolerance under mild reaction conditions. Because alkoxyl radicals can easily undergo β-fragmentations or hydrogen abstractions, this new strategy for deoxygenation of alkoxyl radicals is highly valuable. Moreover, mechanistic studies revealed that the electron-neutral phosphine acts as the deoxygenation reagent.
Phosphinic acid-based MMP-13 inhibitors that spare MMP-1 and MMP-3
Reiter, Lawrence A.,Mitchell, Peter G.,Martinelli, Gary J.,Lopresti-Morrow, Lori L.,Yocum, Sue A.,Eskra, James D.
, p. 2331 - 2336 (2007/10/03)
Phosphinic acid-based inhibitors of MMP-13 have been investigated with the aim of identifying potent inhibitors with high selectivity versus MMP-1. Independent variation of the substituents on a P1′ phenethyl group and a P2 benzyl gr
