66983-94-6
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Basic information
- Product Name: RIBAVIRIN 5'-MONOPHOSPHATE, DILITHIUM SALT
- Synonyms: RIBAVIRIN 5'-MONOPHOSPHATE, DILITHIUM SALT;1-(5-O-Phosphono-β-D-ribofuranosyl)-;Ribavirin 5'-Monophosphate DilithiuM Salt (90%);Ribavirin 5'-monophosphate (lithium salt)
- CAS NO:66983-94-6
- Molecular Formula: C17H19Li2N4O9P
- Molecular Weight: 468.21
- EINECS: N/A
- Product Categories: Anti-virals;Inhibitors;Intermediates & Fine Chemicals;Non-nucleoside Reverse Transcriptase;Pharmaceuticals;Bases & Related Reagents;Carbohydrates & Derivatives;Metabolites & Impurities;Nucleotides
- Mol File: 66983-94-6.mol
- Article Data: 0
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Chemical Properties
- Melting Point: 220°C dec.
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: -20°C Freezer
- Solubility: Aqueous Acid (Slightly), Water (Slightly, Sonicated)
- Stability: Hygroscopic
- CAS DataBase Reference: RIBAVIRIN 5'-MONOPHOSPHATE, DILITHIUM SALT(CAS DataBase Reference)
- NIST Chemistry Reference: RIBAVIRIN 5'-MONOPHOSPHATE, DILITHIUM SALT(66983-94-6)
- EPA Substance Registry System: RIBAVIRIN 5'-MONOPHOSPHATE, DILITHIUM SALT(66983-94-6)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 66983-94-6(Hazardous Substances Data)
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66983-94-6 Usage
Description
Ribavirin 5''-monophosphate inhibits viral DNA and RNA replication in vitro via the strong competitive inhibition of inosine monophosphate dehydrogenase (IMPDH), with a reported Ki value of 270 nM, and thus inhibits guanosine triphosphate synthesis. This agent, a metabolite of the prodrug ribavirin , exhibits broad-spectrum antiviral activity, particularly against myxoviruses. The antiviral effects of ribavirin require conversion to the monophosphate form via adenosine kinase. The anti-HIV activity of ribavirin in cultured human lymphocytes, as well as the anti-influenza activity of this prodrug in MDCK cells, have been attributed to ribavirin 5''-monophosphate.Chemical Properties
RIBAVIRIN 5'-MONOPHOSPHATE, DILITHIUM SALT is SolidUses
Different sources of media describe the Uses of 66983-94-6 differently. You can refer to the following data:1. RIBAVIRIN 5'-MONOPHOSPHATE, DILITHIUM SALT is used as an antiviral agent
2. A metabolite of Ribavirin.
Check Digit Verification of cas no
The CAS Registry Mumber 66983-94-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,9,8 and 3 respectively; the second part has 2 digits, 9 and 4 respectively.Calculate Digit Verification of CAS Registry Number 66983-94:
(7*6)+(6*6)+(5*9)+(4*8)+(3*3)+(2*9)+(1*4)=186
186 % 10 = 6
So 66983-94-6 is a valid CAS Registry Number.
66983-94-6Upstream product
66983-94-6Downstream Products
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RIBAVIRIN 5'-MONOPHOSPHATE, DILITHIUM SALT
