66985-17-9

Basic information

• Product Name: 3-(3-Hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-8-azoniabicyclo(3.2.1)octane bromide monohydrate
• Synonyms: IPRATROPIUM BROMIDE;3-(3-Hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-8-azoniabicyclo(3.2.1)octane bromide monohydrate;Unii-J697uz2A9j;Ipratropium Bromide (100 mg);8-methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl
• CAS NO: 66985-17-9
• Molecular Formula: C20H30NO3.Br.H2O
• Molecular Weight: 430.38
• EINECS: 244-873-8
• Product Categories: VASOTEC
• Mol File: 66985-17-9.mol
• Article Data: 0

Chemical Properties

• Melting Point: 231 °C
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: white/
• Density: g/cm³
• Storage Temp.: 2-8°C
• Solubility: H2O: soluble10mg/mL
• Stability: Hygroscopic
• CAS DataBase Reference: 3-(3-Hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-8-azoniabicyclo(3.2.1)octane bromide monohydrate(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3-Hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-8-azoniabicyclo(3.2.1)octane bromide monohydrate(66985-17-9)
• EPA Substance Registry System: 3-(3-Hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-8-azoniabicyclo(3.2.1)octane bromide monohydrate(66985-17-9)

Safety Data

• Hazard Codes: Xn
• Statements: 20/22-36
• Safety Statements: 26
• RTECS: YM3700000
• Hazardous Substances Data: 66985-17-9(Hazardous Substances Data)

Usage

Chemical Properties

White or almost white, crystalline powder.

Uses

Different sources of media describe the Uses of 66985-17-9 differently. You can refer to the following data:
1. Ipratropium bromide monohydrate has been used for the inhibition of peripheral muscarinic receptors in rats.
2. antihypertensive

Definition

ChEBI: The monohydrate form of ipratropium bromide. An anticholinergic drug, ipratropium bromide blocks the muscarinic cholinergic receptors in the smooth muscles of the bronchi in the lungs. This opens the bronchi, so providing relief in chronic obstructive pulm nary disease and acute asthma.

Biochem/physiol Actions

Ipratropium bromide monohydrate is a nonselective muscarinic acetylcholine receptor antagonist and a bronchodilator. In nebulized form, it is used for treating asthma and obstructive pulmonary diseases. It acts as a β2 adrenoreceptor agonist. Ipratropium bromide monohydrate is an anticholinergic agent and competes with acetylcholine. It promotes bronchodilation by stimulating sympathetic pathways.

Clinical Use

Anticholinergic bronchodilator: Reversible airways obstruction, particularly in COPD

Drug interactions

Potentially hazardous interactions with other drugs None known

Metabolism

After inhalation, around 10-30% of a dose is deposited in the lungs where it exerts its therapeutic effect. Only a small amount of ipratropium reaches the systemic circulation. The majority of a dose is swallowed but is poorly absorbed from the gastrointestinal tract. Ipratropium and its metabolites are eliminated in the urine and faeces.

InChI:InChI=1/C20H30NO3.BrH.H2O/c1-14(2)21(3)16-9-10-17(21)12-18(11-16)24-20(23)19(13-22)15-7-5-4-6-8-15;;/h4-8,14,16-19,22H,9-13H2,1-3H3;1H;1H2/q+1;;/p-1