67-81-2 Usage
Uses
Used in Pharmaceutical Industry:
METHYLTESTOSTERONE is used as a medication for [application reason] due to its androgenic and anabolic effects. It is particularly useful in treating conditions that require hormone replacement or enhancement, such as androgen deficiency, delayed puberty, and osteoporosis.
Used in Sports and Bodybuilding:
METHYLTESTOSTERONE is used as a performance-enhancing drug for [application reason], as it can increase muscle mass, strength, and endurance. It is popular among athletes and bodybuilders seeking to improve their physical performance and appearance.
Used in Research and Development:
METHYLTESTOSTERONE is used as a research compound for [application reason], allowing scientists to study the effects of androgens and anabolic steroids on the human body. This helps in understanding the mechanisms of action and potential therapeutic applications in various medical conditions.
Originator
Penmesterol ,Shanghai Lansheng
Manufacturing Process
A) 14 g of ethyl enolether of androstenedione, melting at 149°-151°C (obtained in a yield of 85% of the theoretical amount by treating androsteaedione with ethyl orthoformate), were added to a boiling solution of37 ml of cyclopentanol and 0.450 g of p-toluenesulfonic acid in 2.5 L of benzene. The mixture was distilled over an approximately 40 minute period, so that the ethanol, which evolved during the exchange reaction, was evaporated off completely.Then 0.5 ml of pyridine was added to the remaining solution and the mixture was concentrated under vacuum to dryness. The residue, taken up with a mixture of methanolmethylene chloride containing a few drops of pyridine, gave 13.8 g of cyclopentyl enolether of androstenedione melting at 181°183°C. Yield about 85%.B) The cyclopentyl enolether of androstenedione was converted to the corresponding cyclopentyl enolether of 17α-methyl testosterone as follows:In a 3-necked flask fitted with a dropping funnel, reflux condenser, stirrer and nitrogen inlet tube, there was placed a solution of 25 g of methyl magnesium bromide in 150 ml of ether. With stirring and under an atmosphere of nitrogen, a solution of 4.1 g of androstenedione 3-cyclopentyl enolether in 80 ml of anhydrous benzene was added slowly. The reaction mixture was refluxed for 1 hour and allowed to stand overnight at room temperature. The mixture was then treated with an aqueous solution of 30% ammonium chloride, the organic layer separated off, washed with water and dried over anhydrous sodium sulfate. The solvent was evaporated and the residue taken up with dilute methanol to yield 3.2 g of a white product. Crystallization from methanol containing few drops of pyridine give the pure 17α-methyltestosterone 3-cyclopentyl enolether; MP: 148-152°C; [α]D =-150° (dioxane).
Therapeutic Function
Androgen
Check Digit Verification of cas no
The CAS Registry Mumber 67-81-2 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 6 and 7 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 67-81:
(4*6)+(3*7)+(2*8)+(1*1)=62
62 % 10 = 2
So 67-81-2 is a valid CAS Registry Number.
InChI:InChI=1/C25H38O2/c1-23-13-10-19(27-18-6-4-5-7-18)16-17(23)8-9-20-21(23)11-14-24(2)22(20)12-15-25(24,3)26/h8,16,18,20-22,26H,4-7,9-15H2,1-3H3/t20?,21?,22?,23-,24-,25-/m0/s1
