670-83-7Relevant articles and documents
Structure-activity relationship studies on 2-heteroaryl-4-arylimidazoles NPY5 receptor antagonists
Elliott, Richard L.,Oliver, Robert M.,LaFlamme, Janet A.,Gillaspy, Melissa L.,Hammond, Marlys,Hank, Richard F.,Maurer, Tristan S.,Baker, Demetria L.,DaSilva-Jardine, Paul A.,Stevenson, Ralph W.,Mack, Christine M.,Cassella, James V.
, p. 3593 - 3596 (2003)
A series of 2-heteroaryl-4-arylimidazoles with potent in vitro activity at the NPY5 receptor was developed. Introduction of electron-withdrawing groups on the 4-aryl ring led to a significant improvement of in vitro potency. Several analogues from this series had anorectic activity in rodent feeding models, but were also found to have undesired behavioral effects in spontaneous locomotor activity.
Structure and Reactivity of Highly Twisted N-Acylimidazoles
Stone, Elizabeth A.,Mercado, Brandon Q.,Miller, Scott J.
supporting information, p. 2346 - 2351 (2019/04/10)
A modular and efficient synthesis of highly twisted N-acylimidazoles is reported. These twist amides were characterized via X-ray crystallography, NMR spectroscopy, IR spectroscopy, and DFT calculations. Modification of the substituent proximal to the amide revealed a maximum torsional angle of 88.6° in the solid state, which may be the most twisted amide reported for a nonbicyclic system to date. Reactivity and stability studies indicate that these twisted N-acylimidazoles may be valuable, namely as acyl transfer reagents.
Rh-Catalyzed Annulation of ortho-C?H Bonds of 2-Arylimidazoles with 1,4,2-Dioxazol-5-ones toward 5-Arylimidazo[1,2-c]quinazolines
Wu, Xiaopeng,Sun, Song,Xu, Shengbo,Cheng, Jiang
supporting information, p. 1111 - 1115 (2018/01/27)
A Rh-catalyzed unique and direct approach for constructing a series of 5-arylimidazo[1,2-c]quinazolines in moderate to excellent yields from simple and readily available 2-arylimidazoles and 3-phenyl-1,4,2-dioxazol-5-ones was described. This procedure pro