67010-18-8

Basic information

• Product Name: Fortimicin A tetrahydrochloride
• CAS NO: 67010-18-8
• Molecular Weight: 551.339
• Mol File: 67010-18-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Fortimicin A tetrahydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Fortimicin A tetrahydrochloride(67010-18-8)
• EPA Substance Registry System: Fortimicin A tetrahydrochloride(67010-18-8)

Safety Data

• Hazardous Substances Data: 67010-18-8(Hazardous Substances Data)

Upstream product

• 55779-06-1 fortimicin A 
• 54783-95-8 fortimicin B 
• 66962-55-8 1,2',6'-tri-N-(benzyloxycarbonyl)fortimicin B 
• 66962-56-9 1,2',6',2''-tetra-N-benzyloxycarbonyl-4-N-methyl-fortimicin A 
• 76801-55-3 1,2',6'-tri-N-acetyl-2-epi-fortimicin B 4,5-carbamate 
• 54783-95-8 2-epi-fortimicin B 
• 66962-55-8 1,2',6'-tri-N-benzyloxycarbonyl-2-epi-fortimicin B 
• 76801-51-9 1,2',6',2''-tetra-N-benzyloxycarbonyl-2-O-(N-benzyloxycarbonyl)glycyl-2-epi-fortimicin A 
• 76801-59-7 2-O-benzyl-1,2',6'-tri-N-benzyloxycarbonyl-2-epi-fortimicin B 
• 76801-57-5 1,2',6'-tri-N-acetyl-2-O-benzyl-2-epi-fortimicin B 4,5-carbamate 
• 76801-58-6 2-O-benzyl-2-epi-fortimicin B 
• 66962-56-9 1,2',6',2''-tetra-N-benzyloxycarbonyl-2-epi-fortimicin A 
• 76801-60-0 2-O-benzyl-1,2',6',2''-tetra-N-benzyloxycarbonyl-2-epi-fortimicin A 
• 54783-95-8 6'-epi-fortimicin B 

Downstream Products

• 66768-12-5 6'-epi-fortimicin A disulfate 
• 66768-12-5 2-epi-fortimicin A disulfate 
• 55779-06-1 fortimicin A 
• 54783-95-8 fortimicin B 
• 71241-90-2 2'-N-glycylfortimicin B 
• 71524-98-6 1,6',2''-tri-N-benzyloxycarbonyl-2'-N-(N-benzyloxycarbonylglycyl)fortimicin A 
• 71524-97-5 1,6'-di-N-benzyloxycarbonyl-2'-N-(N-benzyloxycarbonylglycyl)fortimicin B 
• 71524-99-7 2'-N-glycylfortimicin A tetrahydrochloride 

Relevant articles and documents

PREPARATIONS OF 2-epi-FORTIMICINS A FROM 2-epi-FORTIMICIN B BY INTRAMOLECULAR BASE-CATALYZED 2-O-ACYLATION OF 1,2',6'-TRI-N-BENZYLOXYCARBONYL-2-EPI-FORTIMICIN B

Preparation of 2-epi-fortimicin A (4) from 2-epi-fortimicin B (3) are described.In contrast to the previously reported, selective 4-N-acylation of 1,2',6'-tri-N-benzyloxycarbonylfortimicin B (8) with N-(N-benzyloxycarbonylglycyloxy)succinimide, 1,2',6'-tr

4-N-acylfortimicins B and the preparation of fortimicin A from fortimicin B.

Selective 4-N-acylation of fortimicin B (2) has been accomplished by 4-N-acylation of 1,2',6'-tri-N-benzyloxycarbonylfortimicin B (4) followed by hydrogenolysis of the N-protecting benzyloxycarbonyl groups. In this manner, fortimicin B was converted into fortimicin A (1), and a series of 4-N-acylfortimicins B (3) was prepared for antibacterial assay. The key intermediate, 1,2',6'-tri-N-benzyloxycarbonylfortimicin B, was prepared either directly from fortimicin B or by converting fortimicin A into 1,2',6',2''-tetra-N-benzyloxycarbonylfortimicin A (6a), followed by selective hydrolysis of the 4-N-(N-benzyloxycarbonyl)glycyl group of the latter.