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Aromatic chlorination with thionyl chloride. Applications in the synthesis of chlorinated isoflavones
Soidinsalo, Otto,Waehaelae, Kristiina
, p. 2761 - 2767 (2008/09/19)
Genistein (1) undergoes selective chlorination on treatment with thionyl chloride to give first 8-chlorogenistein (10) and then 6,8-dichlorogenistein (8). Biochanin A (18) gives the 6,8-dichloro derivative 19. A mechanism is suggested for the unexpected a
