67027-12-7Relevant academic research and scientific papers
Cannabis XVII. Pyrolysis of cannabidiol. Structure elucidation of two pyrolytic conversion products
Spronck,Salemink
, p. 185 - 186 (2007/10/14)
Pyrolysis of cannabidiol in a nitrogen atmosphere, which was shown to be a good model for the smoking process, yields a mixture of compounds. Next to the previously described major rearrangement product, we have now isolated and identified two more compounds formed by rearrangement processes: 2-[2-(p-tolyl)propyl]olivetol and 4-(3,4-trans-p-mentha-1,8-dien-3-yl) olivetol.
Cannabis XVIII. Isolation and synthesis of olivetol derivatives formed in the pyrolysis of cannabidiol
Luteyn,Spronck,Salemink
, p. 187 - 190 (2007/10/13)
Pyrolysis of cannabidiol results in the formation of several new cannabinoids and cracking products. In an earlier paper several structures were proposed for the cracking products based on GCMS measurements. In this paper the isolation and synthesis of the majority of these cracking products - which are in general C2-substituted olivetol derivatives - is described. 2,6-Dimethoxy-4-pentylphenyl-lithium and the cuprates derived therefrom proved to be very promising intermediates for the synthesis of olivetol derivatives specifically substituted at C2. The versatility of these reagents is illustrated by several examples.
