67029-74-7

Basic information

• Product Name: 2-BROMO-1-(5-BROMO-2-HYDROXYPHENYL)ETHANONE
• Synonyms: 5-BROMO-2-HYDROXYPHENACYL BROMIDE;2,5'-DIBROMO-2'-HYDROXYACETOPHENONE;2-BROMO-1-(5-BROMO-2-HYDROXYPHENYL)ETHANONE
• CAS NO: 67029-74-7
• Molecular Formula: C₈H₆Br₂O₂
• Molecular Weight: 293.94
• Mol File: 67029-74-7.mol
• Article Data: 9

Chemical Properties

• Melting Point: 66-70 °C
• Boiling Point: 331.5 °C at 760 mmHg
• Flash Point: 154.3 °C
• Appearance: /
• Density: 1.975 g/cm³
• Vapor Pressure: 8.04E-05mmHg at 25°C
• Refractive Index: 1.639
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-BROMO-1-(5-BROMO-2-HYDROXYPHENYL)ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-1-(5-BROMO-2-HYDROXYPHENYL)ETHANONE(67029-74-7)
• EPA Substance Registry System: 2-BROMO-1-(5-BROMO-2-HYDROXYPHENYL)ETHANONE(67029-74-7)

Safety Data

• Hazard Codes: T
• Statements: 25-36/37/38
• Safety Statements: 26-45
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• Hazardous Substances Data: 67029-74-7(Hazardous Substances Data)

Usage

General Description

2-Bromo-1-(5-bromo-2-hydroxyphenyl)ethanone is a chemical compound with the molecular formula C8H6Br2O2. It is a brominated aromatic ketone that is commonly used in organic synthesis and pharmaceutical research. 2-BROMO-1-(5-BROMO-2-HYDROXYPHENYL)ETHANONE contains two bromine atoms and a hydroxyphenyl group attached to a ketone functional group. It has applications in the field of medicinal chemistry and drug discovery, where it is used as a building block for the synthesis of biologically active compounds. Additionally, it is also used as a reagent in various chemical reactions, making it a valuable tool in organic chemistry.

InChI:InChI=1/C8H6Br2O2/c9-4-8(12)6-3-5(10)1-2-7(6)11/h1-3,11H,4H2

Upstream product

• 118-93-4 o-hydroxyacetophenone 
• 2491-36-3 2-(2-bromoacetyl)hydroxybenzene 
• 1450-75-5 5-Bromo-2-hydroxyacetophenone 

Downstream Products

• 1338239-34-1 1-(5-bromo-2-hydroxy-phenyl)-2-(toluene-4-sulfonyl)ethanone 
• 1238715-78-0 S-2-(5-bromo-2-hydroxyphenyl)-2-oxoethyl O-ethyl carbonodithioate 
• 54450-20-3 5-bromo-3(2H)-benzofuranone 
• 1381777-51-0 4-bromo-2-(imidazo[1,2-a]pyridine-2-yl)phenol 

Relevant articles and documents

MeONH 2·hCl-Mediated α-Methylenation/Conjugate Addition of α-Sulfonylo-Hydroxyacetophenones with Methyl Sulfoxides: Route to 3-Sulfonylchroman-4-ones

A novel and efficient route for the synthesis of 3-sulfonylchroman-4-ones from α-sulfonyl o -hydroxyacetophenones with methyl sulfoxides via a MeONH 2·HCl-mediated sequential methylenation/ conjugate addition is described. Plausible reaction mechanisms are proposed and discussed. Various reaction conditions for this novel, one-pot, environmentally friendly conversion were investigated.

Temperature-Controlled Desulfonylative Condensation of α-Sulfonyl o-Hydroxyacetophenones and 2-Formyl Azaarenes: Synthesis of Azaaryl Aurones and Flavones

Temperature-controlled intermolecular desulfonylative condensation of α-sulfonyl o-hydroxyacetophenones with 2-formyl azaarenes (pyridines and quinolones) provides azaaryl (pyridyl and quinolyl) aurones and flavones under warming and refluxing toluene reaction conditions via the formation of the intermediate of sulfonyl chroman-4-one. The uses of various solvents are investigated for facile and efficient transformation. A plausible mechanism is proposed.

3-Hydroxychromone structure-based Raf kinase inhibitor, and preparation method and use thereof

The invention relates to the field of pharmaceutical chemistry, and concretely relates to 3-hydroxychromone compounds (A). R1-R9, X1 and X2 in the compounds (A) are as defined in the description. The invention also discloses preparation methods of the compounds represented by general formula (A), a medicinal composition containing the compounds, and a medicinal use of the compounds, especially a use of the compounds as a Raf kinase inhibitor and a tumor inhibitor.